Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune
disorders involving salivary glands

Bartłomiej Kamiński

doi:10.5114/ms.2020.99545

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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3/2020
vol. 36

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abstract:

Review paper

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Bartłomiej Kamiński

¹

Otolaryngology Ward, Maria Sklodowska-Curie District Hospital, Skarżysko-Kamienna, Poland Head of the Ward: Bartłomiej Kamiński MD, PhD

Medical Studies/Studia Medyczne 2020; 36 (3): 211–218

DOI: https://doi.org/10.5114/ms.2020.99545

Online publish date: 2020/09/30

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Mikulicz’s disease and Sjögren’s syndrome involve salivary glands. They are characterised by lymphocytic infiltrations in affected exocrine glands leading to their swelling and dysfunction. Although they present similar clinical symptoms, currently they belong to different classifications and require different multidisciplinary treatments. This study presents and compares Sjögren’s syndrome and Mikulicz’s disease and reviews their main clinical, histopathological, and serologic criteria and the methods used in the diagnostic process. The most reliable diagnostic method is histopathologic examination of glandular tissue obtained by either minor or major salivary gland biopsies. Serologic criteria play an additional diagnostic role. The different radiological modalities allow the exclusion of other inflammatory and neoplastic processes that can mimic the initial stages of Mikulicz’s disease and Sjögren’s syndrome.

keywords:

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Bartłomiej Kamiński 1

Mikulicz’s disease, Sjögren’s syndrome, IgG4-related diseases

Bartłomiej Kamiński

¹