Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin

Tomasz Wollny; Łukasz Suprewicz; Jolanta Smok-Kalwat; Grażyna Antczak; Ewelina Piktel; Stanisław Góźdź; Bonita Durnaś; Robert Bucki

doi:10.5114/ms.2023.129100

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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2/2023
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abstract:

Original paper

Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin

Tomasz Wollny

¹

,

Łukasz Suprewicz

²

,

Jolanta Smok-Kalwat

¹

,

Grażyna Antczak

¹

,

Ewelina Piktel

³

,

Stanisław Góźdź

⁴

,

Bonita Durnaś

⁵

,

Robert Bucki

^{2, 5}

Holy Cross Cancer Centre, Kielce, Poland
Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland
Independent Laboratory of Nanomedicine, Medical University of Bialystok, Bialystok, Poland
The Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland
The Department of Microbiology and Immunology, Jan Kochanowski University, Kielce, Poland

Medical Studies/Studia Medyczne 2023; 39 (2): 103–113

DOI: https://doi.org/10.5114/ms.2023.129100

Online publish date: 2023/06/30

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AMA

Wollny T, Suprewicz Ł, Smok-Kalwat J, et al. Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin. Medical Studies/Studia Medyczne. 2023;39(2):103-113. doi:10.5114/ms.2023.129100.

APA

Wollny, T., Suprewicz, Ł., Smok-Kalwat, J., Antczak, G., Piktel, E.,  & Góźdź, S. et al. (2023). Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin. Medical Studies/Studia Medyczne, 39(2), 103-113. https://doi.org/10.5114/ms.2023.129100

Chicago

Wollny, Tomasz, Łukasz Suprewicz, Jolanta Smok-Kalwat, Grażyna Antczak, Ewelina Piktel, Stanisław Góźdź,  and Bonita Durnaś et al. 2023. "Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin". Medical Studies/Studia Medyczne 39 (2): 103-113. doi:10.5114/ms.2023.129100.

Harvard

Wollny, T., Suprewicz, Ł., Smok-Kalwat, J., Antczak, G., Piktel, E., Góźdź, S., Durnaś, B.,  and Bucki, R. (2023). Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin. Medical Studies/Studia Medyczne, 39(2), pp.103-113. https://doi.org/10.5114/ms.2023.129100

MLA

Wollny, Tomasz et al. "Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin." Medical Studies/Studia Medyczne, vol. 39, no. 2, 2023, pp. 103-113. doi:10.5114/ms.2023.129100.

Vancouver

Wollny T, Suprewicz Ł, Smok-Kalwat J, Antczak G, Piktel E, Góźdź S et al. Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin. Medical Studies/Studia Medyczne. 2023;39(2):103-113. doi:10.5114/ms.2023.129100.

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Introduction
Plasma gelsolin (pGSN) was recently introduced as a new predictor of systemic inflammation outcomes, especially in critically ill patients. This study aimed to describe the potential interplay between C-reactive protein (CRP), procalcitonin (PCT), and pGSN concentrations in blood collected from patients diagnosed with colon and lung cancer and to assess their diagnostic potential when a combined evaluation of those 3 markers was performed.

Aim of the research
We hypothesized that a correlation between increased blood levels of CRP and PCT and a decreased level of plasma gelsolin might help identify cancer-associated inflammatory responses and a higher risk of poor clinical outcomes.

Material and methods
Blood samples collected from 159 subjects were subjected to the biochemical analysis of CRP and PCT, in addition to the assessment of pGSN levels using Western blotting.

Results
Our results confirmed a significant increase in CRP and PCT concentrations in collected blood samples, while pGSN concentrations decreased. Because the values of the blood CRP, PCT, and pGSN concentration did not show a strong correlation within the tested groups, it might be assumed that the molecular and cell signalling background leading to changes in those markers differs.

Conclusions
A better understanding of the clinical value of the simultaneous evaluation of CRP, PCT, and pGSN levels in patients suffering from rectal and lung cancer might help us identify those with inflammatory responses leading to poor clinical outcomes.

keywords:

Monitoring inflammation in patients diagnosed with non-small cell lung and colorectal cancer using blood levels of C-reactive protein, procalcitonin, and plasma gelsolin

Tomasz Wollny 1 , Łukasz Suprewicz 2 , Jolanta Smok-Kalwat 1 , Grażyna Antczak 1 , Ewelina Piktel 3 , Stanisław Góźdź 4 , Bonita Durnaś 5 , Robert Bucki 2, 5

plasma gelsolin, C-reactive protein, procalcitonin, non-small cell lung cancer, colorectal cancer

Tomasz Wollny

¹

,

Łukasz Suprewicz

²

,

Jolanta Smok-Kalwat

¹

,

Grażyna Antczak

¹

,

Ewelina Piktel

³

,

Stanisław Góźdź

⁴

,

Bonita Durnaś

⁵

,

Robert Bucki

^{2, 5}