Myrrh and artesunate modulate some Th1 and Th2 cytokines secretion in <i>Schistosoma mansoni</i> infected mice

Kadry A. Elbakry; Mohamed M. Abdelaziz

doi:10.5114/ceji.2016.60986

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

2/2016
vol. 41

Send email

Copy url:

abstract:

Experimental immunology

**Myrrh and artesunate modulate some Th1 and Th2 cytokines secretion in Schistosoma mansoni infected mice**

Kadry A. Elbakry

,

Mohamed M. Abdelaziz

(Cent Eur J Immunol 2016; 41 (2): 138-142)

DOI: https://doi.org/10.5114/ceji.2016.60986

Online publish date: 2016/07/15

View full text Get citation

PlumX metrics:

The effects of artesunate and myrrh on S. mansoni infection and the levels of some Th1 and Th2 cytokines were evaluated in the present study. Six weeks after infection, a group of mice was treated with 4 mg/kg of artesunate and other group was treated with 10 mg/kg of myrrh for 3 successive days. Worm burden was reduced with a percentage of 53.7 % and 58.78 % after treatment with myrrh and artesunate respectively as well as the levels of IgG antibodies were significantly reduced compared with infected group. No obvious changes were observed in the level of interferon  after treatment. After treatment with artesunate, interleukin 2 (IL-2) level was significantly decreased, while no significant difference was observed in myrrh-treated group compared with the infected group. On the other hand, the level of IL-10 was not significantly decreased after treatment with artesunate, but it was significantly increased after treatment with myrrh. However, IL-12 levels were significantly decreased after treatment with artesunate. The results demonstrated that, artesunate or myrrh treatment could give a level of protection against S. mansoni infection and modulate the levels of some Th1 and Th2 cytokines in mice infected with S. mansoni.

keywords:

Myrrh and artesunate modulate some Th1 and Th2 cytokines secretion in Schistosoma mansoni infected mice

Kadry A. Elbakry , Mohamed M. Abdelaziz

cytokine, Schistosoma infection, myrrh and artesunate

**Myrrh and artesunate modulate some Th1 and Th2 cytokines secretion in Schistosoma mansoni infected mice**

Kadry A. Elbakry

,

Mohamed M. Abdelaziz