NON-SPECIFIC CONNECTIVE TISSUE DYSPLASIA – A RISK FACTOR FOR POSTOPERATIVE THROMBOSIS IN THE VENOUS SYSTE M OF LOWER EXTREMITIES

Background. Deep vein thrombosis of lower extremities and pulmonary embolism have common pathogenic roots and are the most common cause of poor blood circulation. Several factors that contribute to the development of thrombosis in the venous system are identified and must be taken into consideration in the process of preparing for surgery.

Material and methods. 472 patients were examined and operated in departments of surgery of municipal institution of Ternopil regional council Ternopil University Hospital in 2010-2014. In the process of surgical treatment thromboprophylaxis was applied according to sectoral protocols [1].

Results. In postoperative period thrombotic process i n t he system I VC was diagnosed i n 9 6 (20.34%) patients. The incidence of postoperative thrombosis in the IVC system was directly related to the risk of the venous thromboembolic complications. dysplasia; in 27 (45.1%) observations detected asthenic type of constitution, in 18 (36.6%) – hypermorbid syndrome, in 31 (57.7%) – varicose veins (class C1 – 27 cases, class C2 – 14 cases). In the laboratory study the indicators of metabolic products connective tissue level of total oxyproline exceeded the reference value at 41.77% (p <0.001), free oxyproline – by 46.85% (p <0.001), and bound oxyproline – 31.71% (p <0.001).

Conclusions. Established that non-specific connective tissue dysplasia can be significant risk

factor for postoperative venous thrombosis in the system inferior vena cava.