Neurologic complications in kidney transplant recipients

Piotr C. Piotrowski; Anna Lutkowska; Alexander Tsibulski; Marek Karczewski; Paweł P. Jagodziński

doi:10.5114/fn.2017.68577

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2017
vol. 55

Send email

Copy url:

abstract:

Review paper

Neurologic complications in kidney transplant recipients

Piotr C. Piotrowski

,

Anna Lutkowska

,

Alexander Tsibulski

,

Marek Karczewski

,

Paweł P. Jagodziński

Folia Neuropathol 2017; 55 (2): 86-109

DOI: https://doi.org/10.5114/fn.2017.68577

Online publish date: 2017/06/30

View full text Get citation

PlumX metrics:

Transplantology experiences continuous growth and kidney transplantation is the most frequently transplanted solid organ. Metabolic, cardiovascular, infectious or kidney function-related aspects are widely recognised and are of key interest for transplant doctors. Neurological complications seen in these patients, although known, are less covered in the literature. According to some reports, neurologic symptoms are experienced by almost 9 per 10 transplant recipients. The intensity, severity and type of abnormalities may vary, and most frequently the complications seem to be associated with a direct or indirect effect of immunosuppressive medications, including their direct effect on cells, on blood vessels, and susceptibility to infections. Increasing age of transplant recipients and relaxation of transplantation eligibility criteria enriches the population with patients already compromised, with a higher present risk of stroke, neuropathy, malignancy etc. Research on and introduction to clinical practice of new agents like belatacept, proteasome inhibitors, or modified release formulations of tacrolimus, changes the picture and type of abnormalities within the nervous or neuromuscular system but does not eliminate them. Thus, it seems justified to remind the society of the whole array of neurologic complications they can see in their practice despite advances in the field.

keywords:

Neurologic complications in kidney transplant recipients

Piotr C. Piotrowski , Anna Lutkowska , Alexander Tsibulski , Marek Karczewski , Paweł P. Jagodziński

kidney transplantation, immunosuppression, neurotoxicity, PTLD, PRES, opportunistic infections, CNS

Piotr C. Piotrowski

,

Anna Lutkowska

,

Alexander Tsibulski

,

Marek Karczewski

,

Paweł P. Jagodziński