Neuropathological findings in essential tremor

Ioannis Mavroudis; Foivos Petridis

doi:10.5114/fn.2024.140569

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Review paper

Neuropathological findings in essential tremor

Ioannis Mavroudis

¹

,

Foivos Petridis

²

Leeds Teaching Hospitals, Leeds, United Kingdom
Aristotle University of Thessaloniki, Thessaloniki, Greece

Folia Neuropathol 2024; 62:

DOI: https://doi.org/10.5114/fn.2024.140569

Online publish date: 2024/06/13

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Essential tremor (ET) is one of the most common neurological conditions and the most common movement disorder. The pathophysiological mechanisms that underlie this entity have not yet been described. However, recent post-mortem brain studies have provided useful insight into the underlying pathology of ET. Two brain areas have been consistently found to present neuropathological alterations in patients with ET: the brainstem, for presence of Lewy bodies or neuronal depletion, and the cerebellum, regarding Purkinje cells’ morphology and density. In the present study we aim to review the literature on the main neuropathological findings in ET brains.

keywords:

Neuropathological findings in essential tremor

Ioannis Mavroudis 1 , Foivos Petridis 2

essential tremor, neuropathology, Purkinje cells, locus coeruleus, Lewy bodies

Ioannis Mavroudis

¹

,

Foivos Petridis

²