New international guideline for clozapine titration based on ethnic origin, CRP value and clozapine serum concentration

Alina Wilkowska; Wiesław Jerzy Cubała; Jose de Leon

doi:10.5114/psychs.2023.127919

ISSN: 2720-7048

Psychiatria Spersonalizowana

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2-3/2023
vol. 2

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abstract:

Review paper

New international guideline for clozapine titration based on ethnic origin, CRP value and clozapine serum concentration

Alina Wilkowska

¹

,

Wiesław Jerzy Cubała

¹

,

Jose de Leon

^{2, 3}

Klinika Psychiatrii Dorosłych, Wydział Lekarski, Gdański Uniwersytet Medyczny, Polska
Mental Health Research Center, Eastern State Hospital, Lexington, KY, USA
Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain

Psychiatria Spersonalizowana 2023; 2(2-3): 41–45

DOI: https://doi.org/10.5114/psychs.2023.127919

Online publish date: 2023/06/05

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Clozapine is undoubtedly the most effective treatment of resistant schizophrenia. New international guidelines for clozapine use were published recently. The aim of this paper is to familiarize Polish readers with the guideline containing the most recent data on this subject. The information included in the clozapine package insert is based on old studies and needs actualization. Newer studies bring information about the prevalence of certain serious adverse events connected to clozapine treatment. They also suggest that ethnicity can be a significant factor in clozapine metabolism. One of the ways to prevent adverse events caused by clozapine is by measuring C-reactive protein (CRP) and troponin concentrations. The authors also point out the need for clozapine concentration measurements as a guide to estimating the final dose. We hope that this paper will help popularize the safe use of this extraordinary drug based on the most recent data.

keywords:

New international guideline for clozapine titration based on ethnic origin, CRP value and clozapine serum concentration

Alina Wilkowska 1 , Wiesław Jerzy Cubała 1 , Jose de Leon 2, 3

clozapine, guidelines, safety, adverse reactions, concentration monitoring

Alina Wilkowska

¹

,

Wiesław Jerzy Cubała

¹

,

Jose de Leon

^{2, 3}