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Folia Neuropathologica
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1/2006
vol. 44
 
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abstract:

No association between the brain-derived neurotrophic factor 196G>A or 270C>T polymorphisms and Alzheimer’s or Parkinson’s disease

Marika S. Saarela
,
Terho Lehtimaki
,
Juha O. Rinne
,
Heini Huhtala
,
Riikka Rontu
,
Antti Hervonen
,
Matias Röyttä
,
Jukka-Pekka Ahonen
,
Kari M. Mattila

Folia Neuropathol 2006; 44 (1): 12-16
Online publish date: 2006/03/21
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The brain-derived neurotrophic factor (BDNF) promotes survival, differentiation and maintenance of neurons in the central nervous system. BDNF 196G>A and 270C>T polymorphisms have previously been associated with Alzheimer’s disease (AD) and with Parkinson’s disease (PD). To study the role of BDNF 196G>A and 270C>T polymorphisms in Finnish AD and PD patients we genotyped BDNF 196G>A and 270C>T polymorphisms in 97 sporadic AD patients, 52 PD patients and 101 control subjects with polymerase chain reaction. No associations were found between the genotypes studied and AD or PD in Finnish patients. Moreover, no interaction between either BDNF polymorphism and the ε4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.
keywords:

genotype, polymerase chain reaction, apolipoprotein E
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