Nuclear architecture remodelling in cardiomyocytes with

Anna Fidziańska; Ewa Walczak; Zofia Glinka; Grzegorz Religa

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2008
vol. 46

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abstract:

Nuclear architecture remodelling in cardiomyocytes with

Anna Fidziańska

,

Ewa Walczak

,

Zofia Glinka

,

Grzegorz Religa

Folia Neuropathol 2008; 46 (3): 196-203

Online publish date: 2008/09/19

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We analysed the architecture of cardiomyocyte nuclei lacking lamin A activity in three patients with dilated cardiomyopathy. The diagnosis was established on the basis of clinical and electrophysiological examinations, chest radiography and electrocardiography.
An ultrastructural study of affected cardiomyocytes showed dramatic alterations in nuclear distribution and organization affecting nuclear shape, lamina structure, chromatin and nuclear interior organization. The most specific hallmark of nuclei with lamin A deficiency was the reorganization of the nuclear interior, the appearance of a various number of mitochondria within the nuclear matrix, and focal or total lack of nuclear membrane.

keywords:

Nuclear architecture remodelling in cardiomyocytes with

Anna Fidziańska , Ewa Walczak , Zofia Glinka , Grzegorz Religa

lamin A deficiency, nuclear remodelling, appearance of mitochondria within nuclear interior

Anna Fidziańska

,

Ewa Walczak

,

Zofia Glinka

,

Grzegorz Religa