Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer

Adrian Łukasik; Anna Fila; Bogdan Michalski; Piotr Pordzik; Ryszard Poręba; Tadeusz Wilczok; Urszula Mazurek

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2003
vol. 7

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abstract:

Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF₁₂₁, VEGF₁₄₅, VEGF₁₆₅, VEGF₁₈₃, VEGF₁₈₉, VEGF₂₀₆in squamous intraepithelial lesions and cervical cancer

Adrian Łukasik

,

Anna Fila

,

Bogdan Michalski

,

Piotr Pordzik

,

Ryszard Poręba

,

Tadeusz Wilczok

,

Urszula Mazurek

Współcz Onkol (2003) vol. 7, 4 (286-293)

Online publish date: 2003/06/05

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AMA

Łukasik A, Fila A, Michalski B, et al. Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer. Contemporary Oncology/Współczesna Onkologia. 2003;7(4):286-293.

APA

Łukasik, A., Fila, A., Michalski, B., Pordzik, P., Poręba, R.,  & Wilczok, T. et al. (2003). Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer. Contemporary Oncology/Współczesna Onkologia, 7(4), 286-293.

Chicago

Łukasik, Adrian, Anna Fila, Bogdan Michalski, Piotr Pordzik, Ryszard Poręba, Tadeusz Wilczok,  and Urszula Mazurek. 2003. "Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer". Contemporary Oncology/Współczesna Onkologia 7 (4): 286-293.

Harvard

Łukasik, A., Fila, A., Michalski, B., Pordzik, P., Poręba, R., Wilczok, T.,  and Mazurek, U. (2003). Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer. Contemporary Oncology/Współczesna Onkologia, 7(4), pp.286-293.

MLA

Łukasik, Adrian et al. "Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer." Contemporary Oncology/Współczesna Onkologia, vol. 7, no. 4, 2003, pp. 286-293.

Vancouver

Łukasik A, Fila A, Michalski B, Pordzik P, Poręba R, Wilczok T et al. Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer. Contemporary Oncology/Współczesna Onkologia. 2003;7(4):286-293.

Investigations show, that angiogenesis has largest meaning in process of progression of cervical cancer. Largest proangiogenic working shows VEGF. Well-known is six isoforms, which come into being mRNA: VEGF₁₂₁, VEGF₁₄₅, VEGF₁₆₅, VEGF₁₈₃, VEGF₁₈₉ as well as VEGF₂₀₆on road of alternative maturation. 119 segments (43 segments of proper epithelium, 38 LSIL, 17 HSIL, cervical cancer made up 21 segments in degree of clinical advancement IB – IIB) were pathomorfological estimated and molecular analysis was surrendered. Degree of expression VEGF was estimated (marking quantity of copy mRNA/1 μg RNA in studied tissue). Risk of cancer progression in aspect of occurrence of alternative splice mRNA VEGF forms were estimated. VEGF transcriptive activity in HSIL group was ignificantly higher in comparison with group LSIL and proper tissues of epithelium groups, VEGF transcriptive activity in LSIL group was significantly higher in comparison with proper tissues of epithelium group. Height of VEGF transcriptive activity in studied tissues segments of cervical cancer were not observed. In dependence from affirming isoforms VEGF risk of progression LSIL carries out suitably: for VEGF₁₂₁ – 2.28, for VEGF₁₄₅ – 1.32, for VEGF₁₆₅ – 1.53, for VEGF₁₈₃ – 1.73, for VEGF₁₈₉ – 2.02, for VEGF₂₀₆ – 1.45. In dependence from affirming isoforms VEGF risk of progression HSIL carries out suitably: for VEGF₁₂₁ – 8.94, for VEGF₁₈₉ – 12.95, for VEGF₂₀₆ – 9.81. In dependence from affirming izoformy VEGF risk of progression of cervical cancer carries out suitably: for VEGF₁₂₁ – 9.35, for VEGF₁₆₅ – 5.49, for VEGF₁₈₃ – 4.46, for VEGF₁₈₆ – 3.58, for VEGF₂₀₆ – 21.29.

keywords:

Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206in squamous intraepithelial lesions and cervical cancer

Adrian Łukasik , Anna Fila , Bogdan Michalski , Piotr Pordzik , Ryszard Poręba , Tadeusz Wilczok , Urszula Mazurek

angiogenesis, cervical cancer, squamous intraepithelial lesion, VEGF121, VEGF145, VEGF165, VEGF183, VEGF189, VEGF206

Prognostic significance of occurrence of alternative splice mRNA VEGF forms – VEGF₁₂₁, VEGF₁₄₅, VEGF₁₆₅, VEGF₁₈₃, VEGF₁₈₉, VEGF₂₀₆in squamous intraepithelial lesions and cervical cancer

Adrian Łukasik

,

Anna Fila

,

Bogdan Michalski

,

Piotr Pordzik

,

Ryszard Poręba

,

Tadeusz Wilczok

,

Urszula Mazurek

angiogenesis, cervical cancer, squamous intraepithelial lesion, VEGF₁₂₁, VEGF₁₄₅, VEGF₁₆₅, VEGF₁₈₃, VEGF₁₈₉, VEGF₂₀₆