Original article<br>Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

Kai Kallenberg; Torben Goldmann; Jan Menke; Herwig Strik; Hans C. Bock; Alexander Mohr; Jan H. Buhk; Jens Frahm; Peter Dechent; Michael Knauth

doi:10.5114/fn.2014.45563

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2014
vol. 52

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abstract:

Original article
Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

Kai Kallenberg

,

Torben Goldmann

,

Jan Menke

,

Herwig Strik

,

Hans C. Bock

,

Alexander Mohr

,

Jan H. Buhk

,

Jens Frahm

,

Peter Dechent

,

Michael Knauth

Folia Neuropathol 2014; 52 (3): 226-233

DOI: https://doi.org/10.5114/fn.2014.45563

Online publish date: 2014/09/26

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AMA

Kallenberg K, Goldmann T, Menke J, et al. Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. Folia Neuropathologica. 2014;52(3):226-233. doi:10.5114/fn.2014.45563.

APA

Kallenberg, K., Goldmann, T., Menke, J., Strik, H., Bock, H.,  & Mohr, A. et al. (2014). Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. Folia Neuropathologica, 52(3), 226-233. https://doi.org/10.5114/fn.2014.45563

Chicago

Kallenberg, Kai, Torben Goldmann, Jan Menke, Herwig Strik, Hans C. Bock, Alexander Mohr,  and Jan H. Buhk et al. 2014. "Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging". Folia Neuropathologica 52 (3): 226-233. doi:10.5114/fn.2014.45563.

Harvard

Kallenberg, K., Goldmann, T., Menke, J., Strik, H., Bock, H., Mohr, A., Buhk, J., Frahm, J., Dechent, P.,  and Knauth, M. (2014). Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. Folia Neuropathologica, 52(3), pp.226-233. https://doi.org/10.5114/fn.2014.45563

MLA

Kallenberg, Kai et al. "Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging." Folia Neuropathologica, vol. 52, no. 3, 2014, pp. 226-233. doi:10.5114/fn.2014.45563.

Vancouver

Kallenberg K, Goldmann T, Menke J, Strik H, Bock H, Mohr A et al. Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. Folia Neuropathologica. 2014;52(3):226-233. doi:10.5114/fn.2014.45563.

PlumX metrics:

Introduction: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter – NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized.

Material and methods: Patients’ ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls.

Results: Apparent diffusion coefficient levels of the entire contralateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location.

Conclusions: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor.

keywords:

Original articleAbnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

Kai Kallenberg , Torben Goldmann , Jan Menke , Herwig Strik , Hans C. Bock , Alexander Mohr , Jan H. Buhk , Jens Frahm , Peter Dechent , Michael Knauth

glioma, normal appearing white matter, diffusion tensor imaging

Original article
Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

Kai Kallenberg

,

Torben Goldmann

,

Jan Menke

,

Herwig Strik

,

Hans C. Bock

,

Alexander Mohr

,

Jan H. Buhk

,

Jens Frahm

,

Peter Dechent

,

Michael Knauth