Original article<br>Carotid atheromatous plaques’ instability. Practical implication
of morphologic assessment

Marta Masztalewicz; Przemysław Nowacki; Anna Bajer-Czajkowska; Katarzyna Kotfis; Jowita Biernawska; Maciej Żukowski; Piotr Gutowski

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2012
vol. 50

Send email

Copy url:

abstract:

Original article
Carotid atheromatous plaques’ instability. Practical implication of morphologic assessment

Marta Masztalewicz

,

Przemysław Nowacki

,

Anna Bajer-Czajkowska

,

Katarzyna Kotfis

,

Jowita Biernawska

,

Maciej Żukowski

,

Piotr Gutowski

Folia Neuropathol 2012; 50 (2): 159-165

Online publish date: 2012/06/27

View full text Get citation

The only method giving the possibility of a thorough assessment of plaques instability, is a histologic examination. Three plaques categories were distinguished: unstable, potentially unstable and stable. The distribution of particular types of plaques was similar in symptomatic and asymptomatic patients. Over three quarters of lesions which could correspond to stable plaques in a macroscopic assessment, microscopically fulfilled the criteria for unstable or potentially unstable ones (the number of confirmed stable lesions vs the number of unconfirmed ones, 13 vs. 51 respectively, p < 0.0001). In a microscopic assessment made for all the plaques altogether, 52 plaques (58.4%) were considered unstable; 18 (20.2%) fulfilled the criteria for potentially unstable ones. The remaining 19 plaques (21.4%) were classified as plaques of stable structure. Unstable plaques constituted a significant majority (unstable vs potentially unstable and unstable vs. stable, p = 0.0006 and p = 0.0008 respectively).

Due to the fact that majority of carotid atheromatous plaques appear to be unstable or potentially unstable because of the inflammation and related mechanisms, the role of the inflammatory-immunologic component of atherosclerosis should be used in prophylaxis of stroke and the new therapeutic concepts worked out.

keywords:

Original articleCarotid atheromatous plaques’ instability. Practical implication of morphologic assessment

Marta Masztalewicz , Przemysław Nowacki , Anna Bajer-Czajkowska , Katarzyna Kotfis , Jowita Biernawska , Maciej Żukowski , Piotr Gutowski

carotid plaques, instability, morphologic assessment

Original article
Carotid atheromatous plaques’ instability. Practical implication of morphologic assessment

Marta Masztalewicz

,

Przemysław Nowacki

,

Anna Bajer-Czajkowska

,

Katarzyna Kotfis

,

Jowita Biernawska

,

Maciej Żukowski

,

Piotr Gutowski