Original article Circulated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke

Marta Masztalewicz; Przemysław Nowacki; Anna Bajer-Czajkowska; Katarzyna Kotfis; Jowita Biernawska; Krzysztof Safranow; Maciej Żukowski; Piotr Gutowski

doi:10.5114/fn.2013.37710

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2013
vol. 51

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abstract:

Original article
Circulated CD4⁺CD28^- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke

Marta Masztalewicz

,

Przemysław Nowacki

,

Anna Bajer-Czajkowska

,

Katarzyna Kotfis

,

Jowita Biernawska

,

Krzysztof Safranow

,

Maciej Żukowski

,

Piotr Gutowski

Folia Neuropathol 2013; 51 (3): 250-260

DOI: https://doi.org/10.5114/fn.2013.37710

Online publish date: 2013/09/27

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AMA

Masztalewicz M, Nowacki P, Bajer-Czajkowska A, et al. Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke. Folia Neuropathologica. 2013;51(3):250-260. doi:10.5114/fn.2013.37710.

APA

Masztalewicz, M., Nowacki, P., Bajer-Czajkowska, A., Kotfis, K., Biernawska, J.,  & Safranow, K. et al. (2013). Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke. Folia Neuropathologica, 51(3), 250-260. https://doi.org/10.5114/fn.2013.37710

Chicago

Masztalewicz, Marta, Przemysław Nowacki, Anna Bajer-Czajkowska, Katarzyna Kotfis, Jowita Biernawska, Krzysztof Safranow,  and Maciej Żukowski et al. 2013. "Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke". Folia Neuropathologica 51 (3): 250-260. doi:10.5114/fn.2013.37710.

Harvard

Masztalewicz, M., Nowacki, P., Bajer-Czajkowska, A., Kotfis, K., Biernawska, J., Safranow, K., Żukowski, M.,  and Gutowski, P. (2013). Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke. Folia Neuropathologica, 51(3), pp.250-260. https://doi.org/10.5114/fn.2013.37710

MLA

Masztalewicz, Marta et al. "Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke." Folia Neuropathologica, vol. 51, no. 3, 2013, pp. 250-260. doi:10.5114/fn.2013.37710.

Vancouver

Masztalewicz M, Nowacki P, Bajer-Czajkowska A, Kotfis K, Biernawska J, Safranow K et al. Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke. Folia Neuropathologica. 2013;51(3):250-260. doi:10.5114/fn.2013.37710.

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Background: The question about the role of CD4⁺CD28^– lymphocytes in the pathogenesis of atherosclerosis-related ischemic stroke is still open.

Material and methods: The study included patients, who underwent endarterectomy of internal carotid arteries. The group consisted of patients after stroke and ones without previous stroke. The histopathologic examination of obtained plaques has been performed. The percentage of CD4⁺CD28^– lymphocytes in peripheral blood and their cytotoxicity has been assessed for each patient.

Results: The global percentage of CD4⁺CD28^– lymphocytes in blood was higher in the group of patients with plaques where connective tissue fibers consisted significantly of collagen fibers. The cytotoxicity of analysed cells related to less plaques calcification and presence of cholesterol crystals in the plaque. A multifactor regression of dependent variable presented the last relationship above as a only strong.

Conclusions: CD4⁺CD28^– cytotoxic lymphocytes seem to be involved in carotid atherosclerotic plaques development. Intraplaque cholesterol deposits may contribute to this process.

keywords:

Original articleCirculated CD4+CD28- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke

Marta Masztalewicz , Przemysław Nowacki , Anna Bajer-Czajkowska , Katarzyna Kotfis , Jowita Biernawska , Krzysztof Safranow , Maciej Żukowski , Piotr Gutowski

CD4+CD28– lymphocytes, carotid plaques, stroke

Original article
Circulated CD4⁺CD28^- lymphocytes rate and their cytotoxicity and morphological parameters of internal carotid artery atheromatous plaques in patients with atherosclerosis-related ischemic stroke

Marta Masztalewicz

,

Przemysław Nowacki

,

Anna Bajer-Czajkowska

,

Katarzyna Kotfis

,

Jowita Biernawska

,

Krzysztof Safranow

,

Maciej Żukowski

,

Piotr Gutowski

CD4⁺CD28^– lymphocytes, carotid plaques, stroke