Original article<br>Dendritic and spinal alterations of neurons from Edinger-Westphal nucleus in Alzheimer’s disease

Ioannis Asterios Mavroudis; Marina George Manani; Foivos Petrides; Constantina Petsoglou; Samuel N. Njau; Vasiliki G. Costa; Stavros J. Baloyannis

doi:10.5114/fn.2014.43791

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2014
vol. 52

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abstract:

Original article
Dendritic and spinal alterations of neurons from Edinger-Westphal nucleus in Alzheimer’s disease

Ioannis Asterios Mavroudis

,

Marina George Manani

,

Foivos Petrides

,

Constantina Petsoglou

,

Samuel N. Njau

,

Vasiliki G. Costa

,

Stavros J. Baloyannis

Folia Neuropathol 2014; 52 (2): 197-204

DOI: https://doi.org/10.5114/fn.2014.43791

Online publish date: 2014/06/30

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Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder, causing a progressive decline of intellectual faculties, impairment of behavior and social performance, and impairment of speech eloquence, associated with various neurological manifestations based on a variable neuropathological background. Edinger-Westphal nucleus is a selective target of Alzheimer pathology early in the course of the disease. We attempted to determine the morphological alterations of the dendrites and the dendritic spines in Edinger-Westphal nucleus of 7 cases that fulfilled the diagnostic criteria for Alzheimer’s disease. For the histological study, we applied (a) routine neuropathological techniques and (b) rapid Golgi method. We proceeded to 3D neuronal reconstruction for the estimation of dendritic and spinal changes in Alzheimer’s disease. The morphological and morphometric analysis revealed a substantial neuronal loss and synaptic alterations in Edinger-Westphal nucleus in all the cases of Alzheimer’s disease. Distal dendritic branches are prominently affected. The neuronal loss and alteration of the spines in Edinger-Westphal nucleus in Alzheimer’s disease may be related to the exaggerated pupillary reaction to cholinergic antagonists. Furthermore, the vulnerability of distal branches to Alzheimer’s disease might be related to neuroplasticity impairment.

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Original articleDendritic and spinal alterations of neurons from Edinger-Westphal nucleus in Alzheimer’s disease

Ioannis Asterios Mavroudis , Marina George Manani , Foivos Petrides , Constantina Petsoglou , Samuel N. Njau , Vasiliki G. Costa , Stavros J. Baloyannis

Alzheimer’s disease, Golgi method, 3D neuronal reconstruction, Edinger-Westphal nucleus

Original article
Dendritic and spinal alterations of neurons from Edinger-Westphal nucleus in Alzheimer’s disease

Ioannis Asterios Mavroudis

,

Marina George Manani

,

Foivos Petrides

,

Constantina Petsoglou

,

Samuel N. Njau

,

Vasiliki G. Costa

,

Stavros J. Baloyannis