Original article<br>Differential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours

Niansheng Lai; Hao Zhu; Yijun Chen; Shuai Zhang; Xudong Zhao; Yuchang Lin

doi:10.5114/fn.2014.41746

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2014
vol. 52

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abstract:

Original article
Differential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours

Niansheng Lai

,

Hao Zhu

,

Yijun Chen

,

Shuai Zhang

,

Xudong Zhao

,

Yuchang Lin

Folia Neuropathol 2014; 52 (1): 79-85

DOI: https://doi.org/10.5114/fn.2014.41746

Online publish date: 2014/04/01

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AMA

Lai N, Zhu H, Chen Y, Zhang S, Zhao X, Lin Y. Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours. Folia Neuropathologica. 2014;52(1):79-85. doi:10.5114/fn.2014.41746.

APA

Lai, N., Zhu, H., Chen, Y., Zhang, S., Zhao, X.,  & Lin, Y. (2014). Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours. Folia Neuropathologica, 52(1), 79-85. https://doi.org/10.5114/fn.2014.41746

Chicago

Lai, Niansheng, Hao Zhu, Yijun Chen, Shuai Zhang, Xudong Zhao,  and Yuchang Lin. 2014. "Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours". Folia Neuropathologica 52 (1): 79-85. doi:10.5114/fn.2014.41746.

Harvard

Lai, N., Zhu, H., Chen, Y., Zhang, S., Zhao, X.,  and Lin, Y. (2014). Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours. Folia Neuropathologica, 52(1), pp.79-85. https://doi.org/10.5114/fn.2014.41746

MLA

Lai, Niansheng et al. "Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours." Folia Neuropathologica, vol. 52, no. 1, 2014, pp. 79-85. doi:10.5114/fn.2014.41746.

Vancouver

Lai N, Zhu H, Chen Y, Zhang S, Zhao X, Lin Y. Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours. Folia Neuropathologica. 2014;52(1):79-85. doi:10.5114/fn.2014.41746.

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Introduction: The microRNA, miR-210, is frequently associated with hypoxia induction, and an increase in its levels is often correlated with poor prognosis in many solid tumours. The present study examines the levels of miR-210 in glioma tumours of multiple origins to determine if an association can be established with disease progression.

Material and methods: Tissue samples were acquired from normal brain tissue, oligodendroglial tumours and astrocytic tumours. The astrocytic tumours were further divided by grade: diffuse astrocytomas (WHO grade II), anaplastic astrocytomas (WHO grade III), and glioblastoma (WHO grade IV). The expression of miR-210 was examined by real-time quantitative RT-PCR. The correlation of the expression of miR-210 and astrocytic tumour grade was analyzed by the Spearman correlation test.

Results: MiR-210 presents a differential expression depending on the origin of the glioma. Oligodendroglial tumours exhibit a significantly reduced level of miR-210 as compared with normal brain tissue. In contrast, astrocytic tumours demonstrate significantly increased levels of miR-210. Furthermore, the expression of miR-210 is positively correlated with the grade of astrocytic tumour, in the following order: grade IV > grade III > grade II > normal brain tissue (p < 0.05).

Conclusions: MiR-210 levels can be potentially established as a biomarker for pathological diagnosis of malignant astrocytic tumour progression. In addition, the expression of miR-210 can be utilized as an additional identification measure of glioma tumour origin.

keywords:

Original articleDifferential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours

Niansheng Lai , Hao Zhu , Yijun Chen , Shuai Zhang , Xudong Zhao , Yuchang Lin

astrocytic tumour, oligodendroglial tumour, miR-210, glioma, real-time quantitative RT-PCR

Original article
Differential expression of microRNA-210 in gliomas of variable cell origin and correlation between increased expression levels and disease progression in astrocytic tumours

Niansheng Lai

,

Hao Zhu

,

Yijun Chen

,

Shuai Zhang

,

Xudong Zhao

,

Yuchang Lin