Original article<br>Electrospun nanofiber mat as a protector against the consequences of brain injury

Dorota Sulejczak; Jarosław Andrychowski; Tomasz Kowalczyk; Paweł Nakielski; Małgorzata Frontczak-Baniewicz; Tomasz Kowalewski

doi:10.5114/fn.2014.41744

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2014
vol. 52

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abstract:

Original article
Electrospun nanofiber mat as a protector against the consequences of brain injury

Dorota Sulejczak

,

Jarosław Andrychowski

,

Tomasz Kowalczyk

,

Paweł Nakielski

,

Małgorzata Frontczak-Baniewicz

,

Tomasz Kowalewski

Folia Neuropathol 2014; 52 (1): 56-69

DOI: https://doi.org/10.5114/fn.2014.41744

Online publish date: 2014/04/01

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Traumatic/surgical brain injury can initiate a cascade of pathological changes that result, in the long run, in severe damage of brain parenchyma and encephalopathy. Excessive scarring can also interfere with brain function and the glial scar formed may hamper the restoration of damaged brain neural pathways. In this preliminary study we aimed to investigate the effect of dressing with an L-lactide-caprolactone copolymer nanofiber net on brain wound healing and the fate of the formed glial scar. Our rat model of surgical brain injury (SBI) of the fronto-temporal region of the sensorimotor cortex imitates well the respective human neurosurgery situation. Brains derived from SBI rats with net-undressed wound showed massive neurodegeneration, entry of systemic inflammatory cells into the brain parenchyma and the astrogliosis due to massive glial scar formation. Dressing of the wound with the nanofiber net delayed and reduced the destructive phenomena. We observed also a reduction in the scar thickness. The observed modification of local inflammation and cicatrization suggest that nanofiber nets could be useful in human neurosurgery.

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Original articleElectrospun nanofiber mat as a protector against the consequences of brain injury

Dorota Sulejczak , Jarosław Andrychowski , Tomasz Kowalczyk , Paweł Nakielski , Małgorzata Frontczak-Baniewicz , Tomasz Kowalewski

brain injury, L-lactide-caprolactone copolymer nanofiber net, glial scar, neurodegeneration

Original article
Electrospun nanofiber mat as a protector against the consequences of brain injury

Dorota Sulejczak

,

Jarosław Andrychowski

,

Tomasz Kowalczyk

,

Paweł Nakielski

,

Małgorzata Frontczak-Baniewicz

,

Tomasz Kowalewski