Original article<br>Faulty position of cerebellar cortical neurons as a sequel of disturbed neuronal migration

Milena Laure-Kamionowska; Anna Taraszewska; Danuta Maślińska; Barbara Raczkowska

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2006
vol. 44

Send email

Copy url:

abstract:

Original article
Faulty position of cerebellar cortical neurons as a sequel of disturbed neuronal migration

Milena Laure-Kamionowska

,

Anna Taraszewska

,

Danuta Maślińska

,

Barbara Raczkowska

Folia Neuropathol 2006; 44 (4): 327–332

Online publish date: 2006/12/07

View full text Get citation

The object of our report is the presentation of the morphological picture of cerebellar cortex malformation as a sequel of disturbed neuronal migration. In the disarranged tissue, cavities with a network of meningeal tissue and embedded pathological vessels were noted. The external granule cells did not form a proper external granule layer, but moved deeper, forming irregular aggregates. Abnormally aggregated external granular cells invaded the cerebellar tissue. Abnormal Purkinje cell positioning and a disarranged molecular layer were observed. The normal layered pattern of the cerebellar cortex was disorganized. The presented cases represent a spectrum of morphological changes which are the consequence of aberrant migration. Against a background of vascular pathology affecting the meningoglial network the migration pathways were disrupted. The defective movement of neurons and their faulty maturation resulted in disturbances of cortical layering, and defects of cerebellar folia formation.

keywords:

Original articleFaulty position of cerebellar cortical neurons as a sequel of disturbed neuronal migration

Milena Laure-Kamionowska , Anna Taraszewska , Danuta Maślińska , Barbara Raczkowska

cerebellum, development, cerebellar cortex, cerebellar malformation

Original article
Faulty position of cerebellar cortical neurons as a sequel of disturbed neuronal migration

Milena Laure-Kamionowska

,

Anna Taraszewska

,

Danuta Maślińska

,

Barbara Raczkowska