Original article <br>Immunohistochemical expression of progesterone and estrogen receptors in meningiomas

Aleksandra Omulecka; Wielisław Papierz; Agnieszka Nawrocka-Kunecka; Iwona Lewy-Trenda

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2006
vol. 44

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abstract:

Original article
Immunohistochemical expression of progesterone and estrogen receptors in meningiomas

Aleksandra Omulecka

,

Wielisław Papierz

,

Agnieszka Nawrocka-Kunecka

,

Iwona Lewy-Trenda

Folia Neuropathol 2006; 44 (2): 111-115

Online publish date: 2006/06/23

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In this study we present results of investigations of progesterone and estrogen receptors in most frequent, WHO grade I histological types of meningiomas (meningothelial, fibrous, and transitional) and in atypical – WHO grade II variant of these tumors. Samples from 64 tumors were examined. The cohort consisted of 46 WHO grade I (21 transitional, 13 fibrous and 12 meningothelial histologic variants) and of 18 atypical meningiomas. Apart from immunohistochemical examination of progesterone and estrogen receptors, MIB 1 labeling index was estimated. Positive immunoreaction for progesterone receptors was found in 100% meningothelial, 95% transitional, 46% fibrous and 78% atypical variant of meningiomas. Intensity of immunoreaction was stronger in grade I than in grade II tumors. Immunoexpression of estrogen receptors was found in 48% of the investigated meningiomas. No correlation was stated between WHO grade I and grade II tumors, and between meningothelial, transitional and fibrous variants of the neoplasms.

keywords:

Original article Immunohistochemical expression of progesterone and estrogen receptors in meningiomas

Aleksandra Omulecka , Wielisław Papierz , Agnieszka Nawrocka-Kunecka , Iwona Lewy-Trenda

estrogen receptors, progesterone receptors, meningiomas, proliferation

Original article
Immunohistochemical expression of progesterone and estrogen receptors in meningiomas

Aleksandra Omulecka

,

Wielisław Papierz

,

Agnieszka Nawrocka-Kunecka

,

Iwona Lewy-Trenda