Original article Involvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Samira Razavi; Ali Haeri-Rohani; Akram Eidi; Mohammad R. Zarrindast

doi:10.5114/fn.2014.43788

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2014
vol. 52

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Original article
Involvement of D₂/D₂ dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Samira Razavi

,

Ali Haeri-Rohani

,

Akram Eidi

,

Mohammad R. Zarrindast

Folia Neuropathol 2014; 52 (2): 164-178

DOI: https://doi.org/10.5114/fn.2014.43788

Online publish date: 2014/06/30

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AMA

Razavi S, Haeri-Rohani A, Eidi A, Zarrindast M. Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate. Folia Neuropathologica. 2014;52(2):164-178. doi:10.5114/fn.2014.43788.

APA

Razavi, S., Haeri-Rohani, A., Eidi, A.,  & Zarrindast, M. (2014). Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate. Folia Neuropathologica, 52(2), 164-178. https://doi.org/10.5114/fn.2014.43788

Chicago

Razavi, Samira, Ali Haeri-Rohani, Akram Eidi,  and Mohammad R. Zarrindast. 2014. "Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate". Folia Neuropathologica 52 (2): 164-178. doi:10.5114/fn.2014.43788.

Harvard

Razavi, S., Haeri-Rohani, A., Eidi, A.,  and Zarrindast, M. (2014). Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate. Folia Neuropathologica, 52(2), pp.164-178. https://doi.org/10.5114/fn.2014.43788

MLA

Razavi, Samira et al. "Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate." Folia Neuropathologica, vol. 52, no. 2, 2014, pp. 164-178. doi:10.5114/fn.2014.43788.

Vancouver

Razavi S, Haeri-Rohani A, Eidi A, Zarrindast M. Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate. Folia Neuropathologica. 2014;52(2):164-178. doi:10.5114/fn.2014.43788.

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Glutamatergic system stimulation in some parts of the brain may affect anxiety-related behaviours, aversive learning and memory. This system retains many interactions with dopaminergic neurotransmission. We have studied the effect of nucleus accumbens (NAc) shell glutamatergic system activation on anxiety-related behaviours as well as aversive learning and memory in adult male Wistar rats using the N-methyl-D-aspartate (NMDA) receptor agonist, NMDA. Furthermore, the possible involvement of the NAc shell dopamine D₂ and D₂ receptors upon NMDA-induced effects was evaluated. The elevated plus-maze task was used to assess the drugs’ concomitant effects on anxiety, learning and memory in rats. All drugs were delivered into the NAc shell via bilaterally implanted indwelling cannulae. The NMDA-induced anxiolytic-like behaviours upon retest could possibly be attributed to the further avoidance acquisition impairments. Moreover, the inhibition of dopaminergic system using SCH 23390 and sulpiride induced an anxiolytic-like response and impaired the aversive memory acquisition during retest. However, the concurrent intra-NAc shell microinjection of the subthreshold dose of SCH 23390 and sulpiride (0.125 µg/rat) reversed the anxiolytic-like effect and blocked the aversive memory impairment induced by intra-NAc shell NMDA. Our results suggest a modulatory role of the NAc shell dopaminergic system on NMDA-induced effects in the aversive memory.

keywords:

Original articleInvolvement of D2/D2 dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Samira Razavi , Ali Haeri-Rohani , Akram Eidi , Mohammad R. Zarrindast

glutamate, dopamine, anxiety, aversive learning, elevated plus-maze, nucleus accumbens, rat

Original article
Involvement of D₂/D₂ dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate

Samira Razavi

,

Ali Haeri-Rohani

,

Akram Eidi

,

Mohammad R. Zarrindast