Original article<br>Paeoniflorin attenuates Aβ<sub>25-35</sub>-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction

Jialei Li; Xiaoxia Ji; Jianping Zhang; Guofeng Shi; Xue Zhu; Ke Wang

doi:10.5114/fn.2014.45569

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2014
vol. 52

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abstract:

Original article
Paeoniflorin attenuates Aβ_25-35-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction

Jialei Li

,

Xiaoxia Ji

,

Jianping Zhang

,

Guofeng Shi

,

Xue Zhu

,

Ke Wang

Folia Neuropathol 2014; 52 (3): 285-290

DOI: https://doi.org/10.5114/fn.2014.45569

Online publish date: 2014/09/26

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The pathogenic mechanism of neurodegenerative brain disorder such as Alzheimer’s disease (AD) has been still far from clearly understood. Previous research has identified that mitochondrial dysfunction induced by A has been recognized as a hallmark in AD. Therefore, the effective agents targeting -amyloid (A)-induced mitochondrial dysfunction may be useful for the treatment or prevention of AD. In the present study, the neuroprotective effect of paeoniflorin (PF), one monoterpene glycoside isolated from the Chinese herb Radix Paeoniae alba, on Aβ_25-35-induced toxicity in PC12 cells was investigated for the first time. The results showed that PF could attenuate or restore the cell injury induced by Aβ_25-35 in PC12 cells through preventing mitochondrial dysfunction, including decreased mitochondrial membrane potential, increased cytochrome c release as well as activity of caspase-3 and caspase-9. Therefore, our data provide the evidence that PF could protect PC12 cells against Aβ_25-35-induced neurotoxicity and might be a potentially therapeutic approach for AD in the future.

keywords:

Original articlePaeoniflorin attenuates Aβ25-35-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction

Jialei Li , Xiaoxia Ji , Jianping Zhang , Guofeng Shi , Xue Zhu , Ke Wang

paeoniflorin, Alzheimer’s disease, β-amyloid, mitochondrial dysfunction, PC12 cells

Original article
Paeoniflorin attenuates Aβ_25-35-induced neurotoxicity in PC12 cells by preventing mitochondrial dysfunction

Jialei Li

,

Xiaoxia Ji

,

Jianping Zhang

,

Guofeng Shi

,

Xue Zhu

,

Ke Wang