Original article<br>Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

Małgorzata Ewa Bednarska-Makaruk; Tomasz Krzywkowski; Alla Graban; Wanda Lipczyńska-Łojkowska; Anna Bochyńska; Maria Rodo; Hanna Wehr; Danuta Krystyna Ryglewicz

doi:10.5114/fn.2013.35953

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2013
vol. 51

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abstract:

Original article
Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

Małgorzata Ewa Bednarska-Makaruk

,

Tomasz Krzywkowski

,

Alla Graban

,

Wanda Lipczyńska-Łojkowska

,

Anna Bochyńska

,

Maria Rodo

,

Hanna Wehr

,

Danuta Krystyna Ryglewicz

Folia Neuropathol 2013; 51 (2): 111-119

DOI: https://doi.org/10.5114/fn.2013.35953

Online publish date: 2013/06/26

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AMA

Bednarska-Makaruk M, Krzywkowski T, Graban A, et al. Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia. Folia Neuropathologica. 2013;51(2):111-119. doi:10.5114/fn.2013.35953.

APA

Bednarska-Makaruk, M., Krzywkowski, T., Graban, A., Lipczyńska-Łojkowska, W., Bochyńska, A.,  & Rodo, M. et al. (2013). Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia. Folia Neuropathologica, 51(2), 111-119. https://doi.org/10.5114/fn.2013.35953

Chicago

Bednarska-Makaruk, Małgorzata Ewa, Tomasz Krzywkowski, Alla Graban, Wanda Lipczyńska-Łojkowska, Anna Bochyńska, Maria Rodo,  and Hanna Wehr et al. 2013. "Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia". Folia Neuropathologica 51 (2): 111-119. doi:10.5114/fn.2013.35953.

Harvard

Bednarska-Makaruk, M., Krzywkowski, T., Graban, A., Lipczyńska-Łojkowska, W., Bochyńska, A., Rodo, M., Wehr, H.,  and Ryglewicz, D. (2013). Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia. Folia Neuropathologica, 51(2), pp.111-119. https://doi.org/10.5114/fn.2013.35953

MLA

Bednarska-Makaruk, Małgorzata Ewa et al. "Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia." Folia Neuropathologica, vol. 51, no. 2, 2013, pp. 111-119. doi:10.5114/fn.2013.35953.

Vancouver

Bednarska-Makaruk M, Krzywkowski T, Graban A, Lipczyńska-Łojkowska W, Bochyńska A, Rodo M et al. Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia. Folia Neuropathologica. 2013;51(2):111-119. doi:10.5114/fn.2013.35953.

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Paraoxonase 1 (PON1) activity was determined using phenylacetate as substrate (arylesterase activity) in 304 individuals with dementia – 136 recognised as probable Alzheimer’s disease (AD), 64 as dementia of vascular origin (VaD) and 104 as mixed dementia (MD) and in 129 persons without symptoms of dementia and in a good general health. -108C>T polymorphism in the PON1 gene promoter and p.Q192R polymorphism in the coding region were identified. PON1 activity was significantly lower in demented patients as compared with controls particularly in dementia of a neurodegenerative character (AD and MD). The prevalence of PON1-108T allele carriers was significantly higher in the AD group than in controls. The frequencies of the p.Q192R genotypes did not differ significantly between the investigated groups. An association of the rare T-R haplotype with dementia, particularly with dementia of the neurodegenerative type, was found.

Multivariate regression analysis showed a significant association of PON1 activity with PON1 -108C>T and p.Q192R polymorphisms.

The influence not only of promoter -108C>T, but also of p.Q192R polymorphism on PON1 arylesterase activity was observed. One has to admit that this kind of polymorphism does not preclude interference with the enzyme activity.

It could be concluded that the PON1 gene promoter polymorphism plays an additional role in Alzheimer’s disease development. It seems however that PON1 activity has a dominating influence on the dementia risk.

keywords:

Original articleParaoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

Małgorzata Ewa Bednarska-Makaruk , Tomasz Krzywkowski , Alla Graban , Wanda Lipczyńska-Łojkowska , Anna Bochyńska , Maria Rodo , Hanna Wehr , Danuta Krystyna Ryglewicz

paraoxonase 1 activity, dementia, promoter -108C>T polymorphism, Q192R polymorphism

Original article
Paraoxonase 1 (PON1) gene -108C>T and p.Q192R polymorphisms and arylesterase activity of the enzyme in patients with dementia

Małgorzata Ewa Bednarska-Makaruk

,

Tomasz Krzywkowski

,

Alla Graban

,

Wanda Lipczyńska-Łojkowska

,

Anna Bochyńska

,

Maria Rodo

,

Hanna Wehr

,

Danuta Krystyna Ryglewicz