Original article <br>Research on alteration of neurons in vagal nuclei  in medulla oblongata in newborns with respiratory distress

Hilmi Islami; Ragip Shabani; Driton Shabani; Ramadan Dacaj; Suzana Manxhuka; Mehmedali Azemi; Shaip Krasniqi; Ilir Kurtishi

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2011
vol. 49

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abstract:

Original article
Research on alteration of neurons in vagal nuclei in medulla oblongata in newborns with respiratory distress

Hilmi Islami

,

Ragip Shabani

,

Driton Shabani

,

Ramadan Dacaj

,

Suzana Manxhuka

,

Mehmedali Azemi

,

Shaip Krasniqi

,

Ilir Kurtishi

Folia Neuropathol 2011; 49 (2): 115-122

Online publish date: 2011/07/04

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Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were studied. Material for research was taken from the medulla oblongata and lung tissue. Serial horizontal incisions were made in the medulla oblongata (± 4 mm), commencing from the obex, where the DMNV and nTS vagal nuclei were explored. Fixed cuttings in buffered formalin (10%) were used for histochemical staining. Serial cuttings were done with a microtome (7 µm). Pulmonary infections, being significant (p < 0.05), have an important place when studying respiratory distress (RD) in newborns. Morphological changes of nerve cells in DMNV and nTS nuclei in the medulla oblongata in newborns in different gestational weeks are more emphasized in matures in comparison to aborted and immature (p < 0.05). Depending on the lifetime of dead newborns, neuronal morphological changes in vagus nerve nuclei are significant (p < 0.05). Therefore, it can be concluded that pulmonary infections are often caused due to dramatic respiratory distress in newborns, while hypoxaemic changes in the population of vagus nerve neurons in respiratory distress are more emphasized in matures.

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Original article Research on alteration of neurons in vagal nuclei in medulla oblongata in newborns with respiratory distress

Hilmi Islami , Ragip Shabani , Driton Shabani , Ramadan Dacaj , Suzana Manxhuka , Mehmedali Azemi , Shaip Krasniqi , Ilir Kurtishi

medulla oblongata, DMNV, nTS, lungs of a newborn

Original article
Research on alteration of neurons in vagal nuclei in medulla oblongata in newborns with respiratory distress

Hilmi Islami

,

Ragip Shabani

,

Driton Shabani

,

Ramadan Dacaj

,

Suzana Manxhuka

,

Mehmedali Azemi

,

Shaip Krasniqi

,

Ilir Kurtishi