Original article<br>Size frequency distributions of abnormal protein deposits in Alzheimer’s disease and variant Creutzfeldt-Jakob disease

Richard A. Armstrong

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2007
vol. 45

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abstract:

Original article
Size frequency distributions of abnormal protein deposits in Alzheimer’s disease and variant Creutzfeldt-Jakob disease

Richard A. Armstrong

Folia Neuropathol 2007; 45 (3): 108-114

Online publish date: 2007/08/28

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The size frequency distributions of β-amyloid (Aβ) and prion protein (PrP^sc) deposits were studied in Alzheimer’s disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. Aβ deposits reached a greater maximum size and their distributions were significantly less skewed than the PrP^sc deposits. All distributions were approximately log-normal in shape but only the diffuse PrP^sc deposits did not deviate significantly from a log-normal model. There were fewer larger classic Aβ deposits than predicted and the florid PrP^sc deposits occupied a more restricted size range than predicted by a log-normal model. Hence, Aβ deposits exhibit greater growth than the corresponding PrP^sc deposits. Surface diffusion may be particularly important in determining the growth of the diffuse PrP^sc deposits. In addition, there are factors limiting the maximum size of the Aβ and florid PrP^sc deposits.

keywords:

Original articleSize frequency distributions of abnormal protein deposits in Alzheimer’s disease and variant Creutzfeldt-Jakob disease

Richard A. Armstrong

β-amyloid (Aβ), prion protein (PrPsc), size distribution, log-normal distribution, surface diffusion, protein deposit growth

Original article
Size frequency distributions of abnormal protein deposits in Alzheimer’s disease and variant Creutzfeldt-Jakob disease

β-amyloid (Aβ), prion protein (PrP^sc), size distribution, log-normal distribution, surface diffusion, protein deposit growth