Original article <br>
Some markers of neuronal damage in cerebrospinal fluid  of multiple sclerosis patients in relapse

Krystyna Mitosek-Szewczyk; Wanda Gordon-Krajcer; Dorota Flis; Zbigniew Stelmasiak

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2011
vol. 49

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abstract:

Original article
Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse

Krystyna Mitosek-Szewczyk

,

Wanda Gordon-Krajcer

,

Dorota Flis

,

Zbigniew Stelmasiak

Folia Neuropathol 2011; 49 (3): 191-196

Online publish date: 2011/09/30

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In this paper the performance of cerebrospinal fluid (CSF) protein biomarkers important for monitoring damage of brain astrocytes and neurons for MS is reviewed. We estimated neurofilament, tau and phospho-tau proteins, β-APP, Aβ, S-100B and neuron-specific enolase in CSF of MS patients during relapse. We noted elevation of neurofilament, tau and phospho-tau proteins, S-100B, neuron-specific enolase and c-terminal epitopes of β-APP; concomitantly decrease of Aβ was observed. These CSF biomarkers for MS relapse should reflect the central pathogenic processes in the brain, i.e., axonal and neuronal degeneration.

keywords:

Original article Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse

Krystyna Mitosek-Szewczyk , Wanda Gordon-Krajcer , Dorota Flis , Zbigniew Stelmasiak

multiple sclerosis, neurofilament, tau and phospho-tau proteins, S-100B, β-APP, Aβ-amyloid protein, neuron-specific enolase

Original article
Some markers of neuronal damage in cerebrospinal fluid of multiple sclerosis patients in relapse

Krystyna Mitosek-Szewczyk

,

Wanda Gordon-Krajcer

,

Dorota Flis

,

Zbigniew Stelmasiak