Original paper<br>Association of the rs1801133 variant in the <i>MTHFR </i>gene and sporadic Parkinson’s disease

Silvia García; Ramón Mauricio Coral-Vázquez; Martha P. Gallegos-Arreola; Luis Ángel Montes-Almanza; Patricia Canto; Froylan Arturo García-Martínez; Gerardo Chavira-Hernández; Carlos Palma-Flores; Luis Dávila-Maldonado; Carlos F. Cuevas-García; Luz Berenice López Hernández

doi:10.5114/fn.2015.49971

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2015
vol. 53

Send email

Copy url:

abstract:

Original paper
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease

Silvia García

,

Ramón Mauricio Coral-Vázquez

,

Martha P. Gallegos-Arreola

,

Luis Ángel Montes-Almanza

,

Patricia Canto

,

Froylan Arturo García-Martínez

,

Gerardo Chavira-Hernández

,

Carlos Palma-Flores

,

Luis Dávila-Maldonado

,

Carlos F. Cuevas-García

,

Luz Berenice López Hernández

Folia Neuropathol 2015; 53 (1): 24-28

DOI: https://doi.org/10.5114/fn.2015.49971

Online publish date: 2015/03/24

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

García S, Coral-Vázquez R, Gallegos-Arreola M, et al. Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica. 2015;53(1):24-28. doi:10.5114/fn.2015.49971.

APA

García, S., Coral-Vázquez, R., Gallegos-Arreola, M., Montes-Almanza, L., Canto, P.,  & García-Martínez, F. et al. (2015). Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica, 53(1), 24-28. https://doi.org/10.5114/fn.2015.49971

Chicago

García, Silvia, Ramón Mauricio Coral-Vázquez, Martha P. Gallegos-Arreola, Luis Ángel Montes-Almanza, Patricia Canto, Froylan Arturo García-Martínez,  and Gerardo Chavira-Hernández et al. 2015. "Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease". Folia Neuropathologica 53 (1): 24-28. doi:10.5114/fn.2015.49971.

Harvard

García, S., Coral-Vázquez, R., Gallegos-Arreola, M., Montes-Almanza, L., Canto, P., García-Martínez, F., Chavira-Hernández, G., Palma-Flores, C., Dávila-Maldonado, L., Cuevas-García, C.,  and Hernández, L. (2015). Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica, 53(1), pp.24-28. https://doi.org/10.5114/fn.2015.49971

MLA

García, Silvia et al. "Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease." Folia Neuropathologica, vol. 53, no. 1, 2015, pp. 24-28. doi:10.5114/fn.2015.49971.

Vancouver

García S, Coral-Vázquez R, Gallegos-Arreola M, Montes-Almanza L, Canto P, García-Martínez F et al. Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease. Folia Neuropathologica. 2015;53(1):24-28. doi:10.5114/fn.2015.49971.

PlumX metrics:

The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson’s disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp() = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.

keywords:

Original paperAssociation of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease

Silvia García , Ramón Mauricio Coral-Vázquez , Martha P. Gallegos-Arreola , Luis Ángel Montes-Almanza , Patricia Canto , Froylan Arturo García-Martínez , Gerardo Chavira-Hernández , Carlos Palma-Flores , Luis Dávila-Maldonado , Carlos F. Cuevas-García , Luz Berenice López Hernández

rs1801133, MTHFR, Parkinson’s disease, common variants, C677T, Mexico

Original paper
Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson’s disease