Original paper<br>Daily variability of pancreatic enzyme dose in cystic fibrosis patients

Jarosław Walkowiak; Irmina Spławska; Aleksandra Lisowska; Aleksandra Korzeniewska; Iwona Stelmach; Wojciech Cichy; Juliusz Przysławski

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2007
vol. 2

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abstract:

Original paper
Daily variability of pancreatic enzyme dose in cystic fibrosis patients

Jarosław Walkowiak

,

Irmina Spławska

,

Aleksandra Lisowska

,

Aleksandra Korzeniewska

,

Iwona Stelmach

,

Wojciech Cichy

,

Juliusz Przysławski

Przegląd Gastroenterologiczny 2007; 2 (1): 33–37

Online publish date: 2007/04/05

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Exocrine pancreatic insufficiency is the major cause for maldigestion in cystic fibrosis (CF). Proper pancreatic enzyme supplementation can meaningly improve fat absorbtion and nutritional and clinical status of CF patients. The aim of the study was to assess the adjustment of enzyme supplementation to fat intake in different meals. Material and methods: Fifty CF patients aged 9 months to 26 years (Mean±SD: 11,6±6,0) were introduced in the study. The daily food allowances and enzyme supplementation in different meals were assessed for one day. Energy and fat intake was calculated by the use of MS Access 7,0 application. Results: Dinner provided the highest energy and fat intake. Significant differences in energy intake (expressed as a part of daily intake) were documented between dinner and 2st breakfast, tea-time and supper (p<0.0001 for both). The biggest differences in energy intake as fat were observed between 2nd breakfast and dinner/1st breakfast (p<0.0001 for both). Significant differences were also documented both for global enzyme dosage and dose expressed per kg of body weight (dinner vs. 2nd breakfast, tea-time; p<0,001). The dosage of pancreatic enzymes expressed per γ of ingested fat was slightly different (the highest values for dinner and 1st breakfast and the lowest for tea-time and 2nd breakfast). Conclusions: Enzyme supplementation should be thoroughly monitored in cystic fibrosis patients.

keywords:

Original paperDaily variability of pancreatic enzyme dose in cystic fibrosis patients

Jarosław Walkowiak , Irmina Spławska , Aleksandra Lisowska , Aleksandra Korzeniewska , Iwona Stelmach , Wojciech Cichy , Juliusz Przysławski

cystic fibrosis, pancreatic enzyme supplementation, dosage adjustment

Original paper
Daily variability of pancreatic enzyme dose in cystic fibrosis patients

Jarosław Walkowiak

,

Irmina Spławska

,

Aleksandra Lisowska

,

Aleksandra Korzeniewska

,

Iwona Stelmach

,

Wojciech Cichy

,

Juliusz Przysławski