Original paper<br>Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and hypoxia inducible gene 2 in hemangioblastomas

Mei Li; Jie Song; Peter Pytel

doi:10.5114/fn.2014.45564

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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3/2014
vol. 52

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abstract:

Original paper
Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and hypoxia inducible gene 2 in hemangioblastomas

Mei Li

,

Jie Song

,

Peter Pytel

Folia Neuropathol 2014; 52 (3): 234-242

DOI: https://doi.org/10.5114/fn.2014.45564

Online publish date: 2014/09/26

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Introduction: Hemangioblastomas occur as sporadic or as von Hippel-Lindau syndrome (VHL) associated tumors. In both settings, activation of the VHL-HIF-1 (hypoxia induced factor) pathway is thought to be important in tumor biology.

Material and methods: We performed immunohistochemical studies on 23 hemangioblastomas, 13 meningiomas and 4 hemangiopericytomas to evaluate expression of the VHL-HIF-1 regulated proteins vascular endothelial growth factor (VEGF), carbonic anhydrase IX (CAIX) and hypoxia inducible gene 2 (HIG-2).

Results: Hemangioblastomas showed significantly higher expression of CAIX and VEGF than the other tested tumors. They showed strong membranous expression of CAIX in a pattern identical to that observed in clear cell renal cell carcinomas (CCRCC). Interestingly, hemangioblastomas lacked significant reactivity for HIG-2.

Conclusions: The VHL-HIF-1 regulated genes VEGF and CAIX are expressed in hemangioblastomas but significant HIG-2 expression is not observed. Carbonic anhydrase IX staining in particular may be a helpful marker of hemangioblastomas but does not aid in the distinction from CCRCC.

keywords:

Original paperExpression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and hypoxia inducible gene 2 in hemangioblastomas

Mei Li , Jie Song , Peter Pytel

hemangioblastoma, von Hippel-Lindau, carbonic anhydrase IX

Original paper
Expression of HIF-1 regulated proteins vascular endothelial growth factor, carbonic anhydrase IX and hypoxia inducible gene 2 in hemangioblastomas

Mei Li

,

Jie Song

,

Peter Pytel