Paraneoplastic bullous pemphigoid secondary to cutaneous squamous cell carcinoma

Karolina Zarańska; Barbara Radecka; Kamila Czerw; Grażyna Wąsik

doi:10.5114/dr.2024.146625

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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4/2024
vol. 111

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abstract:

Case report

Paraneoplastic bullous pemphigoid secondary to cutaneous squamous cell carcinoma

Karolina Zarańska

¹

,

Barbara Radecka

^{2, 3}

,

Kamila Czerw

³

,

Grażyna Wąsik

¹

Clinical Department of Dermatology, Regional Hospital, Opole, Poland
Department of Oncology, Institute of Medical Sciences, University of Opole, Opole, Poland
Prof. Tadeusz Koszarowski Opole Oncology Center, Opole, Poland

Dermatol Rev/Przegl Dermatol 2024, 111, 280-284

DOI: https://doi.org/10.5114/dr.2024.146625

Online publish date: 2025/01/17

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Introduction:
Squamous cell carcinoma is the second most common type of skin cancer in humans, with a notable rise in cases in recent years. The occurrence of bullous pemphigoid in association with squamous cell carcinoma is an exceptionally rare phenomenon.

Case report:
The paper presents the case of a 62-year-old male patient who exhibited non-pruritic erythematous and edematous lesions on the trunk. Direct immunofluorescence from the perilesinal skin showed linear deposits of IgG4 and C3 at the dermal-epidermal junction. Physical examination revealed extensive ulceration on the scalp, infiltrating the frontal bone. Based on histopathology and additional imaging tests, the diagnosis of cT4N0M0 squamous cell carcinoma was made.

Conclusions:
Various malignancies can present with bullous pemphigoid, but the paraneoplastic significance of this association remains unclear. The co-occurrence of bullous pemphigoid and squamous cell carcinoma strongly supports a paraneoplastic association.

keywords:

Paraneoplastic bullous pemphigoid secondary to cutaneous squamous cell carcinoma

Karolina Zarańska 1 , Barbara Radecka 2, 3 , Kamila Czerw 3 , Grażyna Wąsik 1

squamous cell carcinoma, paraneoplastic syndromes,bullous pemphigoid

Karolina Zarańska

¹

,

Barbara Radecka

^{2, 3}

,

Kamila Czerw

³

,

Grażyna Wąsik

¹