Photodynamic therapy against onychomycosis

Juliana P. Lyon; Leonardo M. Moreira

doi:10.5114/dr.2020.103888

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2020
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abstract:

Review paper

Photodynamic therapy against onychomycosis

Juliana P. Lyon

¹

,

Leonardo M. Moreira

²

Department of Natural Sciences, Federal University of Sao Joao del Rei, Sao Joao Del Rei, MG, Brazil
Department of Zootechnics, Federal University of Sao Joao Del Rei, Sao Joao Del Rei, MG, Brazil

Dermatol Rev/Przegl Dermatol 2020, 107, 521-533

DOI: https://doi.org/10.5114/dr.2020.103888

Online publish date: 2021/02/27

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Photodynamic therapy (PDT) has been considered a suitable alternative for the treatment of onychomycosis, especially for patients who cannot receive oral antifungal agents or with recurrent infections of the nail. This manuscript intends to analyse the published articles that report the use of PDT in vivo for the treatment of onychomycosis. A PubMed search was conducted with the key words photodynamic therapy and onychomycosis, according to the PRISMA guidelines. Only in vivo studies with clinical and laboratorial evaluations were included in the present study. Fourteen manuscripts were evaluated, according to the inclusion criteria defined, comprising a ten years’ period of studies. The manuscripts differed widely regarding the number of patients involved, photosensitizer employed, protocol details, time of follow up and outcomes. Different parameters should be compared in order to define the best therapeutic approach and to contribute to a more widespread use of PDT in onychomycosis.

keywords:

Photodynamic therapy against onychomycosis

Juliana P. Lyon 1 , Leonardo M. Moreira 2

photodynamic therapy, onychomycosis, PDT, in vivo PDT, photosensitizers, dermatophytosis

Juliana P. Lyon

¹

,

Leonardo M. Moreira

²