Primary cutaneous CD30+ lymphoproliferative disorders: how to diagnose and treat?

Robert Gniadecki; Ewa Lech-Marańda

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2009
vol. 96

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abstract:

Special paper

Primary cutaneous CD30+ lymphoproliferative disorders: how to diagnose and treat?

Robert Gniadecki

,

Ewa Lech-Marańda

Przegl Dermatol 2009, 96, 377-380

Online publish date: 2009/12/29

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Primary cutaneous CD30-positive T-cell lymphoproliferative disorders(pc-CD30+ LPD), which comprise primary cutaneous anaplastic large-cell lymphoma (pc-ALCL) and lymphomatoid papulosis (LyP), are the second most common group of cutaneous T-cell lymphomas. A definite clinical diagnosis is usually reached via the clinical-pathological correlation. The most important differential diagnoses for pc-CD30+ LPD are cutaneous metastases of systemic CD30+ lymphomas, pseudo-lymphomas with CD30+ expression, and large-cell transformation of mycosis fungoides. The prognosis is usually very good. Radiotherapy and low-dose oral methotrexate are the most effective therapies for pc-CD30+ LPD.

keywords:

Primary cutaneous CD30+ lymphoproliferative disorders: how to diagnose and treat?

Robert Gniadecki , Ewa Lech-Marańda

cutaneous T-cell lymphoma, primary cutaneous anaplastic large-cell lymphoma, lympho-matoid papulosis, treatment

Robert Gniadecki

,

Ewa Lech-Marańda