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6/2023
vol. 110
abstract:
Special paper
Primary cutaneous lymphomas. Diagnostic and therapeutic guidelines of the Polish Dermatological Society (PTD) and Polish Lymphoma Research Group (PLRG)
Małgorzata Sokołowska-Wojdyło
1, 2
,
Berenika Olszewska
1, 2
,
Ewa Chmielowska
2, 3, 4
,
Monika Prochorec-Sobieszek
6, 7
,
Grażyna Kamińska-Winciorek
8
,
Aleksandra Lesiak
12, 13
,
Anna Jolanta Woźniacka
5
,
Agnieszka Barbara Owczarczyk-Saczonek
14
,
Joanna Romejko-Jarosińska
15
,
Andrzej Kazimierz Jaworek
16
,
- Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
- Polish Lymphoma Research Group (PLRG)
- Oncology Center, Bydgoszcz, Poland
- Specialist Oncology Hospital, Tomaszów Mazowiecki, Poland
- Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
- Department of Cancer Pathomorphology, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland
- Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland
- Department of Bone Marrow Transplantation and Hematology-Oncology, Maria Skłodowska-Curie National Research Institute
- Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
- Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
- Department of Dermatology, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszów, Rzeszow, Poland
- Department of Dermatology, Paediatric and Oncologic Dermatology, Medical University of Lodz, Lodz, Poland
- Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, Lodz, Poland
- Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland
- Department of Lymphoid Malignancies, Maria Sk³odowska-Curie Institute of Oncology, Warsaw, Poland
- Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland
- Department of Hematology and Transplantology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland
Dermatol Rev/Przegl Dermatol 2023, 110, 647-674
Online publish date: 2024/05/03
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Primary cutaneous lymphomas are a heterogeneous group of rare lymphoproliferative diseases that are initially limited to the skin but potentially also involve the lymph nodes, blood, and occasionally visceral organs. They develop from mature T cells, B cells, and NK cells. The classification includes a wide range of pathologies, each characterized by distinct clinical symptoms and variations in disease course. Cutaneous lymphomas are typically chronic in nature, and a complete cure is rarely achievable. Since primary cutaneous lymphomas are uncommon and present in many variants, they pose diagnostic and therapeutic challenges that require multidisciplinary collaboration between dermatologists, pathologists, hematologists, and oncologists. We present revised guidelines for the diagnosis and treatment of primary cutaneous lymphomas, with the goal of simplifying the diagnostic and therapeutic procedure in routine clinical practice. The guidelines cover the clinical, histopathological, and dermoscopic characteristics of skin lesions, along with recommendations for the diagnostic and therapeutic management of primary cutaneous lymphomas. When selecting the most suitable therapeutic approach for individual patients diagnosed with primary cutaneous lymphoma, the main factor to consider should be the clinical stage of the disease. However, other factors, such as the patient’s age, overall health, and medical history, should also be taken into account. The choice of therapy should be guided by finding optimal efficacy and safety. The guidelines also include globally recognized therapeutic approaches that are currently not accessible in Poland. The recommendations rely on the existing Polish and global guidelines, and the knowledge and experience of experts.
keywords:
diagnosis, treatment, recommendations, mycosis fungoides, primary cutaneous lymphomas
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