Prognostic significance of CEBPA gene mutations in patients with acute myeloid leukemia

Marzena Pieronkiewicz; Krzysztof Lewandowski

doi:10.5114/wo.2010.19151

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2010
vol. 14

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abstract:

Review paper

Prognostic significance of CEBPA gene mutations in patients with acute myeloid leukemia

Marzena Pieronkiewicz

,

Krzysztof Lewandowski

Współczesna Onkologia (2010) vol. 14; 6 (363–371)

DOI: https://doi.org/10.5114/wo.2010.19151

Online publish date: 2011/01/03

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Transcription factors play important role in the process of cells differentiation and intracellular signalling. The gene encoding CEBPA transcription factor is one of the master regulators of granulopoiesis. Mutations of CEBPA are presumed to be involved in emergence and progression of acute myeloid leukemia (AML) and are associated with good prognosis in AML patients. This article pinpoints the role of CEBPA in granulocyte differentiation regulation, types of CEBPA mutations and recommended methods of their identification. Independently, prognostic value of CEBPA mutations alone and with co-existing molecular defects of two other genes: NPM1, FLT3 are discussed in cases of AML with normal karyotype

keywords:

Prognostic significance of CEBPA gene mutations in patients with acute myeloid leukemia

Marzena Pieronkiewicz , Krzysztof Lewandowski

CEBPA, CCAAT enhancer binding protein , granulopoiesis, acute myeloid leukemia, prognosis

Marzena Pieronkiewicz

,

Krzysztof Lewandowski