Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study

Shinichi Ikuta; Takayoshi Nakajima; Masataka Fujikawa; Tsukasa Aihara; Naoki Yamanaka

doi:10.5114/wo.2023.127436

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

Original paper

Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study

Shinichi Ikuta

¹

,

Takayoshi Nakajima

¹

,

Masataka Fujikawa

¹

,

Tsukasa Aihara

¹

,

Naoki Yamanaka

¹

Department of Surgery, Meiwa Hospital, Japan

Contemp Oncol (Pozn) 2023; 27 (2): 65–70

DOI: https://doi.org/10.5114/wo.2023.127436

Online publish date: 2023/05/22

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AMA

Ikuta S, Nakajima T, Fujikawa M, Aihara T, Yamanaka N. Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study. Contemporary Oncology/Współczesna Onkologia. 2023;27(2):65-70. doi:10.5114/wo.2023.127436.

APA

Ikuta, S., Nakajima, T., Fujikawa, M., Aihara, T.,  & Yamanaka, N. (2023). Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study. Contemporary Oncology/Współczesna Onkologia, 27(2), 65-70. https://doi.org/10.5114/wo.2023.127436

Chicago

Ikuta, Shinichi, Takayoshi Nakajima, Masataka Fujikawa, Tsukasa Aihara,  and Naoki Yamanaka. 2023. "Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study". Contemporary Oncology/Współczesna Onkologia 27 (2): 65-70. doi:10.5114/wo.2023.127436.

Harvard

Ikuta, S., Nakajima, T., Fujikawa, M., Aihara, T.,  and Yamanaka, N. (2023). Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study. Contemporary Oncology/Współczesna Onkologia, 27(2), pp.65-70. https://doi.org/10.5114/wo.2023.127436

MLA

Ikuta, Shinichi et al. "Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study." Contemporary Oncology/Współczesna Onkologia, vol. 27, no. 2, 2023, pp. 65-70. doi:10.5114/wo.2023.127436.

Vancouver

Ikuta S, Nakajima T, Fujikawa M, Aihara T, Yamanaka N. Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study. Contemporary Oncology/Współczesna Onkologia. 2023;27(2):65-70. doi:10.5114/wo.2023.127436.

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Introduction:
The geriatric nutritional risk index (GNRI) is an index of nutritional status associated with clinical outcomes in various cancers; however, its prognostic value in biliary tract cancer (BTC) remains to be elucidated. This retrospective study aimed to investigate the association between preoperative GNRI and long-term prognosis of patients with BTC undergoing surgical resection.

Material and methods:
A total of 213 patients were included. The relationships between GNRI and clinicopathological variables, including inflammatory markers such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio, were analysed. The impact of GNRI on overall survival (OS) and relapse-free survival (RFS) was investigated by Kaplan-Meier curves and Cox proportional hazards models.

Results:
Applying a GNRI cut-off of 98, the low-GNRI group comprised 135 patients (63%). The low-GNRI group had elevated carbohydrate antigen 19-9 and CRP levels, high rates of preoperative biliary stenting, lymph node metastases, and perineural invasion, and a lower rate of R0 resection than the high-GNRI group. Both OS and RFS in the low-GNRI group were significantly lower. In multivariate analysis, low GNRI was a significant predictor of poor OS (hazard ratio [HR], 1.731; 95% CI: 1.111–2.696; p = 0.015) and RFS (HR, 1.900; 95% CI: 1.231–2.931; p = 0.004), independently of inflammatory and tumour markers, as well as of pathological features.

Conclusions:
Preoperative GNRI may be an easily accessible predictor of poor prognosis in patients with BTC undergoing surgical resection.

keywords:

Prognostic value of geriatric nutritional risk index for patients with biliary tract cancer undergoing surgical resection – a single-institution retrospective cohort study

Shinichi Ikuta 1 , Takayoshi Nakajima 1 , Masataka Fujikawa 1 , Tsukasa Aihara 1 , Naoki Yamanaka 1

geriatric nutritional risk index, GNRI, biliary tract cancer, BTC, prognosis

Shinichi Ikuta

¹

,

Takayoshi Nakajima

¹

,

Masataka Fujikawa

¹

,

Tsukasa Aihara

¹

,

Naoki Yamanaka

¹