Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats

Beata Dąbrowska-Bouta; Grzegorz Sulkowski; Małgorzata Frontczak-Baniewicz; Dorota Sulejczak; Lidia Strużyńska

doi:10.5114/fn.2023.133796

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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1/2024
vol. 62

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abstract:

Original paper

Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats

Beata Dąbrowska-Bouta

¹

,

Grzegorz Sulkowski

¹

,

Małgorzata Frontczak-Baniewicz

²

,

Dorota Sulejczak

³

,

Lidia Strużyńska

¹

Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
Electron Microscopy Research Unit, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland

Folia Neuropathol 2024; 62 (1): 1-12

DOI: https://doi.org/10.5114/fn.2023.133796

Online publish date: 2024/03/29

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AMA

Dąbrowska-Bouta B, Sulkowski G, Frontczak-Baniewicz M, Sulejczak D, Strużyńska L. Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica. 2024;62(1):1-12. doi:10.5114/fn.2023.133796.

APA

Dąbrowska-Bouta, B., Sulkowski, G., Frontczak-Baniewicz, M., Sulejczak, D.,  & Strużyńska, L. (2024). Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica, 62(1), 1-12. https://doi.org/10.5114/fn.2023.133796

Chicago

Dąbrowska-Bouta, Beata, Grzegorz Sulkowski, Małgorzata Frontczak-Baniewicz, Dorota Sulejczak,  and Lidia Strużyńska. 2024. "Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats". Folia Neuropathologica 62 (1): 1-12. doi:10.5114/fn.2023.133796.

Harvard

Dąbrowska-Bouta, B., Sulkowski, G., Frontczak-Baniewicz, M., Sulejczak, D.,  and Strużyńska, L. (2024). Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica, 62(1), pp.1-12. https://doi.org/10.5114/fn.2023.133796

MLA

Dąbrowska-Bouta, Beata et al. "Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats." Folia Neuropathologica, vol. 62, no. 1, 2024, pp. 1-12. doi:10.5114/fn.2023.133796.

Vancouver

Dąbrowska-Bouta B, Sulkowski G, Frontczak-Baniewicz M, Sulejczak D, Strużyńska L. Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats. Folia Neuropathologica. 2024;62(1):1-12. doi:10.5114/fn.2023.133796.

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Polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) are dominant environmental and food contaminants. Tetrabromobisphenol A (TBBPA) is the most widely used BFR in the world to improve the fire safety of laminates in electrical and electronic equipment. Aroclor 1254, one of the PCBs, is widely distributed in the environment due to its extensive use in industrial applications around the world. Both groups of substances are potent toxicants. There is also increasing evidence that they have neurotoxic effects. In this study we tested the pro-inflammatory effects of Aroclor 1254 and TBBPA based on markers of microglial reactivity and levels of pro-inflammatory factors in the brain of immature rats. Aroclor 1254 or TBBPA were administered to the rats by oral gavage for two weeks at a dose of 10 mg/kg b.w. Both light and electron microscopy studies revealed features indicative of microglia activation in brains of exposed rats. Morphological changes were associated with overexpression of pro-inflammatory enzymes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Analysis of cytokine/chemokine array revealed significant secretion of inflammatory mediators following exposure to both TBBPA and Aroclor 1254, which was stronger in the cerebellum than in the forebrain of exposed immature rats. The results indicate a pro-inflammatory profile of microglia activation as one of the neurotoxic mechanisms of both examined toxicants.

keywords:

Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats

Beata Dąbrowska-Bouta 1 , Grzegorz Sulkowski 1 , Małgorzata Frontczak-Baniewicz 2 , Dorota Sulejczak 3 , Lidia Strużyńska 1

proinflammatory cytokines, COX-2, i-NOS, microglial activation, chemokines, neuroinflammation

Beata Dąbrowska-Bouta

¹

,

Grzegorz Sulkowski

¹

,

Małgorzata Frontczak-Baniewicz

²

,

Dorota Sulejczak

³

,

Lidia Strużyńska

¹