Pyoderma gangrenosum in a patient with Down syndrome

Arletta Kozłowska; Anna Surówka; Andrzej Jaworek; Anna Wojas-Pelc

doi:10.5114/lr.2022.122552

eISSN: 1733-7607
ISSN: 1733-4101

Leczenie Ran

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4/2022
vol. 19

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abstract:

Case report

Pyoderma gangrenosum in a patient with Down syndrome

Arletta Kozłowska

¹

,

Anna Surówka

²

,

Andrzej Jaworek

¹

,

Anna Wojas-Pelc

¹

Katedra i Klinika Dermatologii, Uniwersytet Jagielloński Collegium Medicum w Krakowie
Studenckie Koło Naukowe, Katedra i Klinika Dermatologii, Uniwersytet Jagielloński Collegium Medicum w Krakowie

LECZENIE RAN 2022; 19 (4): 123-128

DOI: https://doi.org/10.5114/lr.2022.122552

Online publish date: 2022/12/23

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Pyoderma gangrenosum (PG) is a rare, potentially fatal skin disease with the formation of a painful, rapidly progressing (dynamic) necrotic ulcer with undermined blue-violet margins. PG in 50-70% of patients coexists with other systemic diseases: inflammatory bowel diseases (most frequent), arthritis (most often rheumatoid arthritis – RA), cancer of internal organs, myeloproliferative syndromes, and other dermatoses.

21-chromosome trisomy (Down’s syndrome – DS) is the most common autosomal genomic mutation among liveborn infants. Due to the coexistence of congenital defects, greater susceptibility to infections, autoimmune diseases, and greater risk of developing neoplastic diseases, patients suffering from DS require multidisciplinary medical supervision.

The aim of the study was to present a 22-year-old patient with DS and coexisting PG hospitalized at the Clinical Department of Dermatology, University Hospital in Krakow. The reminder of this rare and dangerous dermatosis seems to be purposeful and useful, especially for specialists dealing with the treatment of chronic wounds.

keywords:

Pyoderma gangrenosum in a patient with Down syndrome

Arletta Kozłowska 1 , Anna Surówka 2 , Andrzej Jaworek 1 , Anna Wojas-Pelc 1

Down syndrome, pyoderma gangrenosum, diagnostics, treatment

Arletta Kozłowska

¹

,

Anna Surówka

²

,

Andrzej Jaworek

¹

,

Anna Wojas-Pelc

¹