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Folia Neuropathologica
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4/2005
vol. 43
 
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REVIEW ARTICLE
The role of excitotoxicity in neurodegeneration

Elżbieta Salińska
,
Wojciech Danysz
,
Jerzy W. Łazarewicz

Folia Neuropathol 2005; 43 (4): 322-339
Online publish date: 2006/01/06
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A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked by excessive or prolonged activation of the excitatory amino acid receptors may be involved in pathogenesis of brain damage in acute insults and in chronic neurodegenerative diseases. In this review we briefly discuss several selected mechanisms of the excitotoxicity, focusing attention on the role of ionotropic glutamate receptors, calcium transients and calcium-mediated cell injury. In the second part of this paper we provide information on elements of excitotoxicity in brain diseases.
keywords:

calcium, excitatory amino acid receptors, neurodegeneration, NO, oxidative stress
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