REVIEW PAPER<BR>Metalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases

Anna Olewicz-Gawlik; Paweł Hrycaj; Jan K. Łącki

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

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5/2005
vol. 43

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abstract:

REVIEW PAPER
Metalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases

Anna Olewicz-Gawlik

,

Paweł Hrycaj

,

Jan K. Łącki

Ru 2005, 43; 5: 280-285

Online publish date: 2005/10/27

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Metalloproteinases (MMPs) are a family of enzymes that hydrolyze components of the extracellular matrix. These proteinases play a key role in the majority of biological processes, both physiological, such as embryogenesis, wound healing, angiogenesis, and pathological, like for example rheumatic diseases. The increasing number of evidence concerning the role of metalloproteinases in inflammatory rheumatic diseases shows not only the direction of future researches, but also gives new targets for the therapies of these so far incurable diseases.

keywords:

metalloproteinases, rheumatic diseases, inflammation

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REVIEW PAPERMetalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases

Anna Olewicz-Gawlik , Paweł Hrycaj , Jan K. Łącki

metalloproteinases, rheumatic diseases, inflammation

REVIEW PAPER
Metalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases

Anna Olewicz-Gawlik

,

Paweł Hrycaj

,

Jan K. Łącki