Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment

Bruno Fionda; Monica Maria Pagliara; Valentina Lancellotta; Carmela Grazia Caputo; Calogero Casà; Maria Grazia Sammarco; Elisa Placidi; Patrizia Cornacchione; Francesco Boselli; Roberto Iezzi; Cesare Colosimo; Luca Tagliaferri; Maria Antonietta Blasi

doi:10.5114/jcb.2022.113271

eISSN: 2081-2841
ISSN: 1689-832X

Journal of Contemporary Brachytherapy

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abstract:

Original paper

Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment

Bruno Fionda

¹

,

Monica Maria Pagliara

²

,

Valentina Lancellotta

¹

,

Carmela Grazia Caputo

²

,

Calogero Casà

¹

,

Maria Grazia Sammarco

²

,

Elisa Placidi

¹

,

Patrizia Cornacchione

¹

,

Francesco Boselli

³

,

Roberto Iezzi

^{4, 5}

,

Cesare Colosimo

^{4, 5}

,

Luca Tagliaferri

¹

,

Maria Antonietta Blasi

^{2, 3}

U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
U.O.C. Oncologia Oculare, Dipartimento di Scienze dell’Invecchiamento, Neurologiche Ortopediche e Della Testa Collo, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy
Istituto di Oftalmologia, Università Cattolica del Sacro Cuore, Rome, Italy
U.O.C. di Radiologia Diagnostica e Interventistica Generale, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Istituto di Radiologia, Università Cattolica del Sacro Cuore, Rome, Italy

J Contemp Brachytherapy 2022; 14, 1: 96–106

DOI: https://doi.org/10.5114/jcb.2022.113271

Online publish date: 2022/02/04

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AMA

Fionda B, Pagliara M, Lancellotta V, et al. Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment. Journal of Contemporary Brachytherapy. 2022;14(1):96-106. doi:10.5114/jcb.2022.113271.

APA

Fionda, B., Pagliara, M., Lancellotta, V., Caputo, C., Casà, C.,  & Sammarco, M. et al. (2022). Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment. Journal of Contemporary Brachytherapy, 14(1), 96-106. https://doi.org/10.5114/jcb.2022.113271

Chicago

Fionda, Bruno, Monica Maria Pagliara, Valentina Lancellotta, Carmela Grazia Caputo, Calogero Casà, Maria Grazia Sammarco,  and Elisa Placidi et al. 2022. "Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment". Journal of Contemporary Brachytherapy 14 (1): 96-106. doi:10.5114/jcb.2022.113271.

Harvard

Fionda, B., Pagliara, M., Lancellotta, V., Caputo, C., Casà, C., Sammarco, M., Placidi, E., Cornacchione, P., Boselli, F., Iezzi, R., Colosimo, C., Tagliaferri, L.,  and Blasi, M. (2022). Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment. Journal of Contemporary Brachytherapy, 14(1), pp.96-106. https://doi.org/10.5114/jcb.2022.113271

MLA

Fionda, Bruno et al. "Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment." Journal of Contemporary Brachytherapy, vol. 14, no. 1, 2022, pp. 96-106. doi:10.5114/jcb.2022.113271.

Vancouver

Fionda B, Pagliara M, Lancellotta V, Caputo C, Casà C, Sammarco M et al. Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment. Journal of Contemporary Brachytherapy. 2022;14(1):96-106. doi:10.5114/jcb.2022.113271.

Uveal melanoma (UM) is the most common intra-ocular tumor in Caucasian adults and may derive from melanocytes. Historically, the first therapeutic approach to treat UM has been surgical removal of the eye, with obvious consequences in terms of function, cosmesis, and psychological impact on patients.

Collaborative Ocular Melanoma Study (COMS) introduced the first uniform approach to perform interventional radiotherapy (IRT – brachytherapy) procedure in a standardized way that allowed to demonstrate equivalence of IRT with enucleation in terms of overall survival. Since this milestone, several international guidelines have been issued with regard to several technical aspects of this procedure, which has become the mainstream therapy worldwide. However, nowadays, there is still a lack of consensus about the criteria to definitively assess UM response after IRT.

We present a collection of paradigmatic cases treated in our institution, and then discuss in detail the latest available evidence on the topic.

keywords:

Radiological and clinical findings in uveal melanoma treated by plaque interventional radiotherapy (brachytherapy): Visual atlas and literature review on response assessment

Bruno Fionda 1 , Monica Maria Pagliara 2 , Valentina Lancellotta 1 , Carmela Grazia Caputo 2 , Calogero Casà 1 , Maria Grazia Sammarco 2 , Elisa Placidi 1 , Patrizia Cornacchione 1 , Francesco Boselli 3 , Roberto Iezzi 4, 5 , Cesare Colosimo 4, 5 , Luca Tagliaferri 1 , Maria Antonietta Blasi 2, 3

uveal melanoma, interventional radiotherapy, brachytherapy, plaque