Relationship between -238A/G and -308A/G polymorphisms in the promoter region of TNF-α and susceptibility to gout in the Chinese Han male population

Shiguo Liu; Hui Wang; Changgui Li

doi:10.5114/ceji.2013.39760

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2013
vol. 38

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abstract:

Relationship between -238A/G and -308A/G polymorphisms in the promoter region of TNF-α and susceptibility to gout in the Chinese Han male population

Shiguo Liu

,

Hui Wang

,

Changgui Li

(Centr Eur J Immunol 2013; 38 (4): 449-453)

DOI: https://doi.org/10.5114/ceji.2013.39760

Online publish date: 2013/12/30

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The study has investigated whether -238A/G and -308A/G polymorphisms in the promoter region of TNF-α are associated with susceptibility to gout in the Chinese Han male population. Two hundred and thirty eight gout patients and 263 gout-free controls were enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the genotypes and allelic frequencies of TNF-α-238A/G and -308A/G. No statistically significant difference was found in the genotypes (for TNF-α-238A/G, χ² = 1.741, DF = 1, p = 0.187, OR = 0.646, 95% CI: 0.336-1.241; for TNF-α-308A/G, χ² = 1.893, DF = 2, p = 0.388) or allelic frequencies (for TNF-α-238A/G, χ² =

= 1.669, DF = 1, p = 0.196, OR = 1.520, 95% CI: 0.802-2.882; for TNF-α-308A/G, χ² = 0.032, DF = 1,

p = 0.857, OR = 0.957, 95% CI: 0.590-1.552) of TNF-α-238A/G and -308A/G polymorphisms between patients and controls. The -238A/G and -308A/G polymorphisms in the promoter region of TNF-α are not associated with susceptibility to gout and thus do not play a major role in the development of gout in the Chinese Han male population.

keywords:

Relationship between -238A/G and -308A/G polymorphisms in the promoter region of TNF-α and susceptibility to gout in the Chinese Han male population

Shiguo Liu , Hui Wang , Changgui Li

TNF-α, polymorphism, gout, Han Chinese

Shiguo Liu

,

Hui Wang

,

Changgui Li