Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Weiwei Li; Luli Huang; Weimei Cai; Sue Cao; Yan Yuan; Sheng Lu; Yanzheng Zhao; Ping Lu

doi:10.5114/wo.2014.41391

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2015
vol. 19

Send email

Copy url:

abstract:

Original paper

Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Weiwei Li

,

Luli Huang

,

Weimei Cai

,

Sue Cao

,

Yan Yuan

,

Sheng Lu

,

Yanzheng Zhao

,

Ping Lu

Contemp Oncol (Pozn) 2015; 19 (1): 17–21

DOI: https://doi.org/10.5114/wo.2014.41391

Online publish date: 2015/03/26

View full text Get citation

PlumX metrics:

Introduction: To assess the potential association between serotonin transporter gene insertion/deletion polymorphism and the cancer-related constipation phenotype.

Material and methods: A total of 120 patients diagnosed with malignant solid tumors were subjected to genotyping. For the two groups – patients with constipation and constipation-free patients with non-gastrointestinal cancer, 60 cases in each group – we collected the peripheral venous blood. We extracted genomic DNA, and used polymerase chain reaction (PCR) to analyze the serotonin transporter (5-HT) link polymorphic region (5-HTTLPR) polymorphism of the serotonin transporter gene.

Results: The frequency of S/S genotype in cancer patients with constipation was 66.67% (40/60), and the frequency of the S allele was 79.17% (95/120); the frequency of S/S genotype in cancer patients without constipation was 48.33% (29/60), and the frequency of the S allele was 65.83% (79/120). There was a significant difference between the two groups (p < 0.05).

Conclusions: The presence of 5-HTTLPR S/S genotype and the S allele in patients with cancers probably carry an increased risk of constipation. However, its role as a cause of cancer-related constipation needs to be further investigated.

keywords:

Relationship between serotonin transporter gene polymorphism and constipation in cancer patients

Weiwei Li , Luli Huang , Weimei Cai , Sue Cao , Yan Yuan , Sheng Lu , Yanzheng Zhao , Ping Lu

cancer, constipation, serotonin transporter, genetic polymorphism

Weiwei Li

,

Luli Huang

,

Weimei Cai

,

Sue Cao

,

Yan Yuan

,

Sheng Lu

,

Yanzheng Zhao

,

Ping Lu