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Alergologia Polska - Polish Journal of Allergology
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2/2024
vol. 11
 
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abstract:
Original paper

Relationship between the switched memory B level and clinical course of coronavirus disease 2019 in patients with common variable immunodeficiency

Filiz Sadi Aykan
1
,
Fatih Çölkesen
1
,
Eray Yıldız
2
,
Mehmet Kılınç
1
,
Recep Evcen
1
,
Şevket Arslan
1

  1. Department of Allergy and Clinical Immunology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
  2. Department of Allergy and Clinical Immunology, Necip Fazıl City Hospital, Kahramanmaraş, Turkey
Alergologia Polska – Polish Journal of Allergology 2024; 11, 2: 148–153
DOI: https://doi.org/10.5114/pja.2024.140356
Online publish date: 2024/06/07
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Introduction:
Among the primary immunodeficiency spectrum, the most common symptomatic type is common variable immunodeficiency (CVID).

Aim:
This study aims to investigate the relationship of class-switched memory B cells (cSMBCs) (CD19+CD27+IgD−) with the clinical course of coronavirus disease-2019 (COVID-19) in patients with CVID.

Material and methods:
This single-centre retrospective study evaluated the clinical features, serum immunoglobulin (Ig) levels, and cSMBC levels of 24 polymerase chain reaction (PCR)-confirmed patients with CVID and COVID-19. The COVID-19 disease severity classification, mortality rate, hospitalisation, symptoms, and PCR positivity durations of the patients were recorded.

Results:
The median age of CVID patients included in the study was 48 (32–58), and 15 of them (62.5%) were female. Disease was severe in 8 (33%) patients, 3 (12.5%) of whom were followed in the intensive care unit and died. The serum IgA, IgM, and CD19+ B lymphocyte cell levels were similar between the mild-moderate and severe disease groups. The cSMBC level was significantly lower in the severe disease group (p = 0.01). The hospitalisation, COVID-19 symptom, and PCR positivity durations were significantly longer in the group with a low cSMBC level (p < 0.05). The cSMBC level was negatively correlated with PCR positivity duration (r = 0.397, p = 0.038).

Conclusions:
The cSMBC level is related to the clinical course of COVID-19 in patients with CVID. The cSMBC levels has prognostic value in patients with COVID-19.

keywords:

COVID-19, primary immunodeficiency, common variable immunodeficiency, B lymphocytes, class-switched memory B cells


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