Review article<br>Proteinaceous intracellular inclusions in neurodegenerative disorders

Dorota Dziewulska; Janina Rafałowska

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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2/2005
vol. 43

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abstract:

Review article
Proteinaceous intracellular inclusions in neurodegenerative disorders

Dorota Dziewulska

,

Janina Rafałowska

Folia Neuropathol 2005; 43 (2): 51-63

Online publish date: 2005/06/22

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Neurodegenerative disorders are characterized by accumulation of ”toxic”, pathologic proteins in brain cells. Mutations in genes coding these proteins result in conformational disturbances of the protein structure and their accumulation and aggregation manifesting at the level of light microscope as various intracellular inclusions. This paper is an attempt of approach cellular mechanisms underlying neurodegenerative disorders with special attention to mechanisms of protein elimination.

keywords:

Review articleProteinaceous intracellular inclusions in neurodegenerative disorders

Dorota Dziewulska , Janina Rafałowska

aggresome, α-synuclein, autophagy, proteasome, ubiquitin, tau protein

Review article
Proteinaceous intracellular inclusions in neurodegenerative disorders

Dorota Dziewulska

,

Janina Rafałowska