Review article<br>The role of glycogen synthase kinase 3β in disorders of the central nervous system

Jan K. Nowak

eISSN: 2084-9885
ISSN: 1896-6764

Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology

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1/2011
vol. 6

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abstract:

Review article
The role of glycogen synthase kinase 3β in disorders of the central nervous system

Jan K. Nowak

Neuropsychiatria i Neuropsychologia 2011; 6, 1: 25–35

Online publish date: 2011/07/14

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The β isoform of glycogen synthase kinase 3 enzyme (GSK3β), which is found at particularly high concentrations in the central nervous system, is crucial for its proper development and functioning. The role of GSK3β in the pathogenesis of affective disorders, schizophrenia and Alzheimer’s disease, as well as its involvement in other neurological disorders and neurogenesis, is discussed. A hypothesis is proposed that inhibitory phosphorylation of GSK3β induced by non-selective cyclooxygenase (COX) inhibitors mediates the non-selective COX inhibitors’ Alzheimer’s disease and Parkinson’s disease risk-lowering effects. Throughout the review special attention is paid to the therapeutic potential of GSK3β inhibitors. Supplementary information on GSK3β cellular activity regulation, the place of GSK3β in the Wnt signalling pathway, the link between GSK3β and memory, neuroplasticity and circadian rhythms is provided.

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Review articleThe role of glycogen synthase kinase 3β in disorders of the central nervous system

Jan K. Nowak

GSK3β, affective disorders, schizophrenia, Alzheimer disease, neurogenesis

Review article
The role of glycogen synthase kinase 3β in disorders of the central nervous system