Review paper<br>Disturbances of glucose metabolism in patients with pheochromocytoma

Katarzyna Denisewicz

eISSN: 2084-9877
ISSN: 1896-9666

Przegląd Kardiodiabetologiczny/Cardio-Diabetological Review

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2/2009
vol. 4

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abstract:

Review paper
Disturbances of glucose metabolism in patients with pheochromocytoma

Katarzyna Denisewicz

Przegląd Kardiodiabetologiczny 2009; 4, 2: 87–89

Online publish date: 2009/08/07

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Disturbances of glucose metabolism are observed in many endocrinopathies as an effect of enhanced secretion of counter- -regulatory hormones, such as growth hormone, catecholamines, glucocorticosteroids, aldosterone and glucagon. In patients with pheochromocytoma, impaired glucose tolerance results from multiple mechanisms, mainly from inhibition of insulin secretion, stimulation of gluconeogenesis and glycogenolysis, as well as enhanced lipolysis. Increased glucose levels are observed in 50% of patients with pheochromocytoma, while diabetes is diagnosed in 15-48% of cases. Patients usually show the features of type 2 diabetes and do not require insulin treatment. Administration of a-adrenergic drugs before operation does not significantly improve carbohydrate tolerance but after tumour resection full retreat of diabetes symptoms is observed.

keywords:

Review paperDisturbances of glucose metabolism in patients with pheochromocytoma

Katarzyna Denisewicz

pheochromocytoma, diabetes mellitus, insulin resistance

Review paper
Disturbances of glucose metabolism in patients with pheochromocytoma