Review paper<br>Neurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Ryszard Pluta; Anna Bogucka-Kocka; Marzena Ułamek-Kozioł; Wanda Furmaga-Jabłońska; Sławomir Januszewski; Judyta Brzozowska; Mirosław Jabłoński; Janusz Kocki

doi:10.5114/fn.2015.52405

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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abstract:

Review paper
Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Ryszard Pluta

,

Anna Bogucka-Kocka

,

Marzena Ułamek-Kozioł

,

Wanda Furmaga-Jabłońska

,

Sławomir Januszewski

,

Judyta Brzozowska

,

Mirosław Jabłoński

,

Janusz Kocki

Folia Neuropathol 2015; 53 (2): 89-99

DOI: https://doi.org/10.5114/fn.2015.52405

Online publish date: 2015/06/30

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AMA

Pluta R, Bogucka-Kocka A, Ułamek-Kozioł M, et al. Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?. Folia Neuropathologica. 2015;53(2):89-99. doi:10.5114/fn.2015.52405.

APA

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S.,  & Brzozowska, J. et al. (2015). Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?. Folia Neuropathologica, 53(2), 89-99. https://doi.org/10.5114/fn.2015.52405

Chicago

Pluta, Ryszard, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Judyta Brzozowska,  and Mirosław Jabłoński et al. 2015. "Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?". Folia Neuropathologica 53 (2): 89-99. doi:10.5114/fn.2015.52405.

Harvard

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M.,  and Kocki, J. (2015). Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?. Folia Neuropathologica, 53(2), pp.89-99. https://doi.org/10.5114/fn.2015.52405

MLA

Pluta, Ryszard et al. "Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?." Folia Neuropathologica, vol. 53, no. 2, 2015, pp. 89-99. doi:10.5114/fn.2015.52405.

Vancouver

Pluta R, Bogucka-Kocka A, Ułamek-Kozioł M, Furmaga-Jabłońska W, Januszewski S, Brzozowska J et al. Review paperNeurogenesis and neuroprotection in postischemic 
brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?. Folia Neuropathologica. 2015;53(2):89-99. doi:10.5114/fn.2015.52405.

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For thousands of years, humankind has used plants for therapeutics. Nowadays, there is a renewed public interest in naturally occurring treatments with minimal toxicity and diets related to health. Alterations in hippocampal neurogenesis have been recognized as an integral part of brain ischemia. Neuronal stem/progenitor cells in the hippocampus are positively and negatively regulated by intrinsic and extrinsic agents. One positive regulator of neurogenesis in the hippocampus is curcumin in the diet. This review provides an assessment of the current state of the field in hippocampal neurogenesis and neuroprotection studies in brain ischemia and focuses on the role of curcumin in the diet. Data suggest that dietary intake of curcumin enhances neurogenesis. Recent studies performed in ischemic models have suggested that curcumin also has neuroprotective features. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent ageing-associated changes in cellular proteins that lead to protein insolubility and aggregation after ischemia such as β-amyloid peptide and tau protein. Here, we also review the evidence from ischemic models that curcumin improves cognition and health span by overexpression of life supporting genes and preventing or delaying the onset of neurodegenerative changes. Available data provide evidence that curcumin induces neurogenesis and neuroprotection and may provide a novel therapeutic agent for both regenerative medicine and for the treatment of neurodegenerative diseases such as postischemic brain neurodegeneration with Alzheimer phenotype.

keywords:

Review paperNeurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Ryszard Pluta , Anna Bogucka-Kocka , Marzena Ułamek-Kozioł , Wanda Furmaga-Jabłońska , Sławomir Januszewski , Judyta Brzozowska , Mirosław Jabłoński , Janusz Kocki

brain ischemia, neurodegeneration, dementia, neurogenesis, neuroprotection, curcumin

Review paper
Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Ryszard Pluta

,

Anna Bogucka-Kocka

,

Marzena Ułamek-Kozioł

,

Wanda Furmaga-Jabłońska

,

Sławomir Januszewski

,

Judyta Brzozowska

,

Mirosław Jabłoński

,

Janusz Kocki