Review paper<br>Psoriasis as a disease associated with the immune system disorders

Dorota Chomiczewska-Skóra; Ewa Trznadel-Grodzka; Helena Rotsztejn

doi:10.5114/ceji.2013.34370

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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vol. 38

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abstract:

Review paper
Psoriasis as a disease associated with the immune system disorders

Dorota Chomiczewska-Skóra

,

Ewa Trznadel-Grodzka

,

Helena Rotsztejn

(Centr Eur J Immunol 2013; 38 (1): 129-133)

DOI: https://doi.org/10.5114/ceji.2013.34370

Online publish date: 2013/04/18

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The etiopathogenesis of psoriasis has not been fully elucidated. Nowadays, psoriasis is perceived as a multifactorial disease of genetic origin, in which complex immunological disorders concerning specific and non-specific defense mechanisms play a key role. Researchers emphasize the systemic and inflammatory character of the disease, its autoimmunological aspect and, above all, its dependence on T cells – Th1, Th17 and recently Th22. T cells with type 1 cytokine profile (Th1 and Tc1), Th17 and Th22 lymphocytes, regulatory T cells, NK and NK-T cells, antigen-presenting cells (dendritic cells, including Langerhans cells), keratinocytes, neutrophils, monocytes and makrophages are among the cells that take part in the pathogenesis of psoriasis.

keywords:

Review paperPsoriasis as a disease associated with the immune system disorders

Dorota Chomiczewska-Skóra , Ewa Trznadel-Grodzka , Helena Rotsztejn

psoriasis, lymphocytes, dendritic cells, cytokines

Review paper
Psoriasis as a disease associated with the immune system disorders

Dorota Chomiczewska-Skóra

,

Ewa Trznadel-Grodzka

,

Helena Rotsztejn