Review paper<br>Statins and the risk of liver damage

Tomasz Mach

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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2/2007
vol. 2

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abstract:

Review paper
Statins and the risk of liver damage

Tomasz Mach

Przegląd Gastroenterologiczny 2007; 2 (2): 111–115

Online publish date: 2007/05/29

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Statins inhibit cholesterol biosynthesis, and successfully prevent coronary heart disease. This paper presents the results of randomized trials and meta-analyses concerning side effects of statins, particularly increased aminotransferases in patients with chronic liver damage. The most frequent side effect of statin therapy is myopathy, and increased activity of aminotransferases in serum is rare (1-3% of patients), usually less than three times the upper limit of normal range. Patients with increased aminotransferases and treated with statins do not have increased risk of progression of liver function. Statin therapy is not associated with a higher risk of severe hepatotoxicity in patients with nonalcoholic steatohepatitis and chronic viral hepatitis type C.

keywords:

Review paperStatins and the risk of liver damage

Tomasz Mach

statins, cholesterol, liver, fatty liver

Review paper
Statins and the risk of liver damage