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Reumatologia/Rheumatology
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Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2006
vol. 44
 
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abstract:

Review paper
The ups and downs of non-steroidal anti-inflammatory drugs

Barbara Lisowska
,
Maria Rell-Bakalarska
,
Lidia Rutkowska-Sak

Ru 2006; 44, 2: 106-111
Online publish date: 2006/04/28
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Conventional non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the metabolism of arachidonic acid to proinflammatory prostaglandins (PGs) by cyclooxygenase COX-1 and COX-2. Non-steroidal anti-inflammatory drugs provide important analgesic and anti-inflammatory benefits to millions of patients, but are associated with a number of serious adverse events. These include gastrointestinal toxicity, renal impairment, cardiovascular and thromboembolic complications. The mechanism underlying the serious complications associated with conventional NSAIDs and selective cyclooxygenase COX-2 inhibitors treatment is more complicated than simple imbalance between COX-1 and COX-2 inhibition and still is not clear. A recent opinions on benefit-risk balance associated with NSAIDs treatment are presented in this report
keywords:

non-steroidal anti-inflammatory drugs (NSAIDs), mechanism of action, benefit-risk balance
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