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Reumatologia/Rheumatology
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Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
6/2006
vol. 44
 
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Review paper
Toxic epidermal necrolysis

Mariusz Puszczewicz
,
Marta Ociepa-Zawal

Reumatologia 2006; 44, 6: 353–358
Online publish date: 2006/12/15
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Toxic epidermal necrolysis (TEN, Lyell’s syndrome) is a life-threatening disease of the epidermis and mucous membranes, appearing after exposure to certain drugs. The metabolites of drugs produced in keratinocytes activate the in situ synthesis of TNF-α followed by the process of apoptosis. The symptoms of TEN are erythema multiforme, flaccid bullae and epidermal necrosis followed by massive loss of epidermis of skin and mucosa as well. TEN mortality rate is between 30% to 40%. The therapy of TEN patients includes monitoring of fluid balance and the prevention of systemic infections. Specific therapy for TEN (corticosteroids, cyclosporin A, cyclophosphamide, iv immunoglobulin) is still controversial.
keywords:

toxic epidermal necrolysis, sulphonamides, lupus erythomatosus
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