Review papers<br>Are mast cells the Trojan horse in HIV-1 infection?

Piotr Witczak; Ewa Brzezińska-Błaszczyk

doi:10.5114/ceji.2012.32729

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2012
vol. 37

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abstract:

Review papers
Are mast cells the Trojan horse in HIV-1 infection?

Piotr Witczak

,

Ewa Brzezińska-Błaszczyk

(Centr Eur J Immunol 2012; 37 (4): 382-386)

DOI: https://doi.org/10.5114/ceji.2012.32729

Online publish date: 2013/02/10

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Mast cells are multifunctional, long-lived cells, widely distributed throughout vascularized tissues. Currently, more and more data indicate that mast cells are susceptible to HIV-1 infection at the progenitor stage of their ontogeny. Progenitor mast cells display expression of surface molecule CD4 as well as chemokine receptors, i.e. CCR5 and CXCR4, prerequisite for HIV-1 cell entry. Interestingly, there are some factors, including certain cytokines and HIV-1 proteins, that modify surface molecule expression and, consequently, affect the mast cell susceptibility to HIV-1. HIV-1-infected progenitor mast cells are distributed to various tissues where mature and become HIV-1 resistant. However, mature mast cells retain the virus in latent form which might be reactivated via Toll-like receptor (TLR) stimulation or IgE cross-linking. Thus, mast cells could serve as a reservoir for HIV-1 replication and spread.

keywords:

Review papersAre mast cells the Trojan horse in HIV-1 infection?

Piotr Witczak , Ewa Brzezińska-Błaszczyk

mast cells, human immunodeficiency virus (HIV), acquired immunodeficiency syndrome (AIDS)

Review papers
Are mast cells the Trojan horse in HIV-1 infection?

Piotr Witczak

,

Ewa Brzezińska-Błaszczyk